Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases.
Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases.
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DOI：
10.1016/j.drudis.2010.06.011
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发表时间：
2010-08
影响因子：
7.4
通讯作者：
Yu, Cheuk-Man
中科院分区：
文献类型：
--
作者：
Dong, Ming;Yan, Bryan P.;Liao, James K.;Lam, Yat-Yin;Yip, Gabriel W. K.;Yu, Cheuk-Man
Rho/Rho-Kinase(ROCK)通路在多种心血管疾病的发病机制中起重要作用。ROCK的激活参与了血管张力、内皮功能障碍、炎症和重塑的调节。ROCK的抑制在多种心血管疾病中都有有益的作用。来自动物模型和临床使用的岩石抑制剂的证据，如Y-27632、法舒地尔和他汀类药物(即多效性效应)，支持岩石是潜在的治疗靶点的假设。本文就ROCK通路在血管功能调节中的作用以及ROCK抑制剂在心血管疾病治疗中的应用作一综述。
The Rho/rho-kinase (ROCK) pathway has an important role in the pathogenesis of several cardiovascular diseases. The activation of ROCK is involved in the regulation of vascular tone, endothelial dysfunction, inflammation and remodeling. The inhibition of ROCK has a beneficial effect in a variety of cardiovascular disorders. Evidence from animal models and from clinical use of ROCK inhibitors, such as Y-27632, fasudil and statins (i.e. pleiotropic effects), supports the hypothesis that ROCK is a potential therapeutic target. This review provides a current understanding of the role of ROCK pathway in the regulation of vascular function and the use of ROCK inhibitors in the treatment of cardiovascular disorders.
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影响因子：
37.8
作者：
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通讯作者：
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