New-onset glucose disorders in peritoneal dialysis patients: a meta-analysis and systematic review.
New-onset glucose disorders in peritoneal dialysis patients: a meta-analysis and systematic review.
复制标题
腹膜透析患者新发血糖异常：荟萃分析和系统评价。
DOI：
10.1093/ndt/gfz116
复制
发表时间：
2020-08
影响因子：
6.1
通讯作者：
Mao Zhi-Guo
中科院分区：
文献类型：
--
作者：
Xue Cheng;Gu Yan-Yan;Cui Cheng-Ji;Zhou Chen-Chen;Wang Xian-Dong;Ruan Meng-Na;Huang Lin-Xi;Chen Si-Xiu;Yang Bo;Chen Xu-Jiao;Qian Yi-Xin;Wu Jun;Zhao Xue-Zhi;Zhang Yu-Qiang;Mei Chang-Lin;Zhang Shou-Lin;Xu Jing;Mao Zhi-Guo
背景
BACKGROUND
Peritoneal dialysis (PD) patients are at high risk of developing glucose metabolism disturbance (GMD). The incidence and prevalence of new-onset GMD, including diabetes mellitus (DM), impaired glucose tolerance (IGT) and impaired fast glucose (IFG), after initiation of PD, as well as their correlated influence factors, varies among studies in different areas and of different sample sizes. Also, the difference compared with hemodialysis (HD) remained unclear. Thus we designed this meta-analysis and systematic review to provide a full landscape of the occurrence of glucose disorders in PD patients.
METHODS
We searched the MEDLINE, Embase, Web of Science and Cochrane Library databases for relevant studies through September 2018. Meta-analysis was performed on outcomes using random effects models with subgroup analysis and sensitivity analysis.
RESULTS
We identified 1124 records and included 9 studies involving 13 879 PD patients. The pooled incidence of new-onset DM (NODM) was 8% [95% confidence interval (CI) 4-12; I2 = 98%] adjusted by sample sizes in PD patients. Pooled incidence rates of new-onset IGT and IFG were 15% (95% CI 3-31; I2 = 97%) and 32% (95% CI 27-37), respectively. There was no significant difference in NODM risk between PD and HD [risk ratio 0.99 (95% CI 0.69-1.40); P = 0.94; I2 = 92%]. PD patients with NODM were associated with an increased risk of mortality [hazard ratio 1.06 (95% CI 1.01-1.44); P < 0.001; I2 = 92.5%] compared with non-DM PD patients.
CONCLUSIONS
Around half of PD patients may develop a glucose disorder, which can affect the prognosis by significantly increasing mortality. The incidence did not differ among different ethnicities or between PD and HD. The risk factor analysis did not draw a definitive conclusion. The glucose tolerance test should be routinely performed in PD patients.
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DOI：
10.1016/s0140-6736(16)00618-8
发表时间：
2016-04-09
期刊：
Lancet (London, England)
影响因子：
--
作者：
NCD Risk Factor Collaboration (NCD-RisC)
通讯作者：
NCD Risk Factor Collaboration (NCD-RisC)
影响因子：
1.6
作者：
A. Tuzcu;M. Bahçeci;M. Yılmaz;C. Turgut;I. Kara
通讯作者：
A. Tuzcu;M. Bahçeci;M. Yılmaz;C. Turgut;I. Kara
影响因子：
19.6
作者：
Y. Bouffard;S. Tissot;B. Delafosse;J. Viale;G. Annat;O. Bertrand;J. Motin
通讯作者：
Y. Bouffard;S. Tissot;B. Delafosse;J. Viale;G. Annat;O. Bertrand;J. Motin
影响因子：
168.9
作者：
Jha, Vivekanand;Garcia-Garcia, Guillermo;Yang, Chih-Wei
通讯作者：
Yang, Chih-Wei
影响因子：
2.5
作者：
Hong Xu;J. Carrero
通讯作者：
Hong Xu;J. Carrero