Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study.
Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study.
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DOI：
10.1186/bcr2613
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Dores GM
中科院分区：
文献类型：
--
作者：
Ghabach B;Anderson WF;Curtis RE;Huycke MM;Lavigne JA;Dores GM
乳腺腺样囊性癌是一种罕见的特殊类型的基底细胞样癌，缺乏基于人群的描述性数据。我们试图提供有关美国乳腺癌发病率、相对存活率和相关癌症风险的新的基于人群的信息。使用监测、流行病学和最终结果计划的数据，我们计算了年龄调整的发病率(IRS)、IR比(IRR)、乳腺癌的相对存活率和其他癌症的标准化发病率(SIRS)。在1977至2006年间，总共有338名妇女(IR=0.92/100万人年)被诊断出患有乳房-ACC。黑人的IRS比白人低39%(IRR=0.61，95%可信区间=0.37至0.96)，并且IRS在30年内保持不变。95%的病例具有局限性分期(n=320；IR=0.87)，其中雌激素受体(ER)阴性/孕激素受体(PR)阴性肿瘤的IR最高(IR=0.56)。像其他典型的ER阴性肿瘤一样，特定年龄的IRS一直增加到中年，然后停滞不前。5年、10年和15年的相对生存率分别为98.1%、94.9%和91.4%。(SIR=0.89，95%可信区间=0.43~1.64)或之前(SIR=0.71，95%可信区间=0.28~1.46)，女性乳腺癌的危险性不增加。同样，没有观察到乳腺癌与所有其他癌症合并、实体瘤或淋巴造血系统恶性肿瘤的风险。女性乳腺癌的特点是ER/PR阴性表达，少见区域淋巴结转移，预后良好，存活率高，无相关肿瘤。这些发现加强了针对乳腺癌的个体化治疗的重要性，并证实了基底细胞样乳腺癌的明显异质性。
Adenoid cystic carcinoma of the breast (breast-ACC) is a rare and special type of basal-like tumor for which scant population-based descriptive data exist. We sought to provide new population-based information on breast-ACC incidence, relative survival, and associated cancer risk in the United States. Using data from the Surveillance, Epidemiology and End Results Program, we calculated age-adjusted incidence rates (IRs), IR ratios (IRRs), and relative survival for breast-ACC, and standardized incidence ratios (SIRs) for other cancers. Overall 338 women (IR = 0.92/1 million person-years) were diagnosed with breast-ACC during 1977 to 2006. Blacks had 39% lower IRs than Whites (IRR = 0.61, 95% confidence interval = 0.37 to 0.96), and IRs remained constant over the 30-year period. Ninety-five percent of cases presented with localized stage (n = 320; IR = 0.87), and the highest IRs were observed for estrogen receptor (ER)-negative/progesterone receptor (PR)-negative tumors (IR = 0.56). Like other typically ER-negative tumors, age-specific IRs increased until midlife and then plateaued. Five-year, 10-year, and 15-year relative survival was 98.1%, 94.9%, and 91.4%, respectively. The risk of female breast cancer was not increased following (SIR = 0.89, 95% confidence interval = 0.43 to 1.64) or preceding (SIR = 0.71, 95% confidence interval = 0.28 to 1.46) breast-ACC. Similarly, no association was observed for breast-ACC and risk of all other cancers combined, solid tumors, or lymphohematopoietic malignancies. Breast-ACC among women is characterized by ER-negative/PR-negative expression, rare regional lymph node involvement, a favorable prognosis with excellent survival, and absence of associated cancers. These findings reinforce the importance of tailored treatments for breast-ACC and lend credence to the apparent heterogeneity of basal-like breast cancers.
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影响因子：
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作者：
KOLLER, M;RAM, Z;LIPSHITZ, M
通讯作者：
LIPSHITZ, M
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5
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