Taxonomy and Characterization of Bioactive Metabolites from a New Marine Microorganism Strain MLA-21
Taxonomy and Characterization of Bioactive Metabolites from a New Marine Microorganism Strain MLA-21
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新海洋微生物菌株 MLA-21 生物活性代谢物的分类和表征
DOI：
10.14233/ajchem.2013.12909
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发表时间：
2014
影响因子：
--
通讯作者：
Xi, Tao
中科院分区：
文献类型：
--
作者：
Xing, Yingying;Ma, Yihua;Lu, Yuanyuan;Xi, Tao
海洋放线菌 MLA-21 是从北极沉积物样品中分离出来的。通过形态学、生理学和化学分类学表征以及16S rRNA基因序列分析等方法对该菌株进行鉴定。结果表明，该菌株为S. coelicolour海洋变种新种。从该菌株的发酵过程中分离纯化出两种活性化合物，并通过体外细胞毒活性测定确定它们对HepG-2、MCF-7和A549细胞系的抗肿瘤活性。通过 1 H 和 13 C NMR 以及 EI-MS 光谱方法将其结构阐明为对羟基苯甲酸甲酯 (1) 和 3-(4-丙基苯氧基)-丙酸 (2)。化合物1和2为首次从海洋微生物中分离得到。 s,
Marine actinomyces MLA-21 was isolated from Arctic sediment samples. The strain was identified by the methods of morphology, physiological and chemotaxonomic characterization and 16S rRNA gene sequence analysis. The results showed that the strain was a new marine variable species of S. coelicolour . Two active compounds were isolated and purified from the fermentation of the strain and their antitumor activity against HepG-2, MCF-7 and A549 cell lines were defined by vitro cytotoxic activity assay. Their structures were elucidated as methyl p -hydroxybenzoate ( 1 ) and 3-(4-propylphenoxy)-propanoic acid ( 2 ) by 1 H and 13 C NMR and EI-MS spectroscopic methods. Compounds 1 and 2 were isolated from marine microorganism for the first time. s,
DOI：
10.1002/9781444313949.ch14
发表时间：
1951-02
期刊：
The Yale Journal of Biology and Medicine
影响因子：
--
作者：
L. Mond;J. Fulton;H. Schuman;J. Donne;B. Jonson
通讯作者：
L. Mond;J. Fulton;H. Schuman;J. Donne;B. Jonson