African Swine Fever Virus: A Review.
African Swine Fever Virus: A Review.
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DOI：
10.3390/life12081255
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发表时间：
2022-08-17
期刊：
影响因子：
3.2
通讯作者：
Chen, Jinding
中科院分区：
文献类型：
--
作者：
Li, Zhaoyao;Chen, Wenxian;Qiu, Zilong;Li, Yuwan;Fan, Jindai;Wu, Keke;Li, Xiaowen;Zhao, Mingqiu;Ding, Hongxing;Fan, Shuangqi;Chen, Jinding
非洲猪瘟（ASF）是一种病毒性疾病，家猪和野猪的死亡率都很高。非洲猪瘟给养猪国家带来了巨大挑战，也对区域和国家猪肉产品贸易产生了负面影响。迄今为止，ASF已遍布非洲、欧洲和亚洲。为了控制非洲猪瘟的爆发，迫切需要开发安全有效的非洲猪瘟疫苗。非洲猪瘟病毒（ASF virus，ASFV）是非洲猪瘟的病原体，基因组庞大，结构复杂。其近一半的病毒基因的功能仍有待探索。了解ASFV蛋白的结构和功能，ASFV感染和免疫的机制，以及鉴定主要的免疫原性基因将有助于ASF疫苗的开发。本文综述了ASFV的结构、复制、蛋白功能、毒力基因、免疫逃避、灭活、疫苗、控制和诊断等方面的研究进展。
African swine fever (ASF) is a viral disease with a high fatality rate in both domestic pigs and wild boars. ASF has greatly challenged pig-raising countries and also negatively impacted regional and national trade of pork products. To date, ASF has spread throughout Africa, Europe, and Asia. The development of safe and effective ASF vaccines is urgently required for the control of ASF outbreaks. The ASF virus (ASFV), the causative agent of ASF, has a large genome and a complex structure. The functions of nearly half of its viral genes still remain to be explored. Knowledge on the structure and function of ASFV proteins, the mechanism underlying ASFV infection and immunity, and the identification of major immunogenicity genes will contribute to the development of an ASF vaccine. In this context, this paper reviews the available knowledge on the structure, replication, protein function, virulence genes, immune evasion, inactivation, vaccines, control, and diagnosis of ASFV.
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