Data Rich, Information Poor: Can We Use Electronic Health Records to Create a Learning Healthcare System for Pharmaceuticals?
Data Rich, Information Poor: Can We Use Electronic Health Records to Create a Learning Healthcare System for Pharmaceuticals?
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DOI：
10.1002/cpt.1226
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发表时间：
2019-04
影响因子：
6.7
通讯作者：
Paris V
中科院分区：
文献类型：
--
作者：
Eichler HG;Bloechl-Daum B;Broich K;Kyrle PA;Oderkirk J;Rasi G;Santos Ivo R;Schuurman A;Senderovitz T;Slawomirski L;Wenzl M;Paris V
明智地使用真实的世界数据（RWD）有望使药物开发和使用的所有步骤更加有效和高效，包括研发、监管决策、卫生技术评估、定价和报销决策以及治疗。需要一个基于电子健康记录和其他常规收集数据的“学习型医疗保健系统”，以充分利用RWD的潜力，补充基于随机对照试验的证据。我们描述并举例说明了对学习型医疗保健系统日益增长的需求;我们将未来高效制药生态系统的迫切要求与最近发布的经济合作与发展组织（OECD）报告中强调的当前缺陷进行了对比;我们反思了从医疗保健数据过渡到可操作信息所需的步骤。需要所有利益攸关方的协调努力和国际合作，以加快学习型医疗保健系统的实施速度，使每个人都受益。
Judicious use of real‐world data (RWD) is expected to make all steps in the development and use of pharmaceuticals more effective and efficient, including research and development, regulatory decision making, health technology assessment, pricing, and reimbursement decisions and treatment. A “learning healthcare system” based on electronic health records and other routinely collected data will be required to harness the full potential of RWD to complement evidence based on randomized controlled trials. We describe and illustrate with examples the growing demand for a learning healthcare system; we contrast the exigencies of an efficient pharmaceutical ecosystem in the future with current deficiencies highlighted in recently published Organisation for Economic Co‐operation and Development (OECD) reports; and we reflect on the steps necessary to enable the transition from healthcare data to actionable information. A coordinated effort from all stakeholders and international cooperation will be required to increase the speed of implementation of the learning healthcare system, to everybody's benefit.
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影响因子：
2.6
作者：
Kurz X;Perez-Gutthann S;ENCePP Steering Group
通讯作者：
ENCePP Steering Group
影响因子：
16.6
作者：
Koyama S;Akbay EA;Li YY;Herter-Sprie GS;Buczkowski KA;Richards WG;Gandhi L;Redig AJ;Rodig SJ;Asahina H;Jones RE;Kulkarni MM;Kuraguchi M;Palakurthi S;Fecci PE;Johnson BE;Janne PA;Engelman JA;Gangadharan SP;Costa DB;Freeman GJ;Bueno R;Hodi FS;Dranoff G;Wong KK;Hammerman PS
通讯作者：
Hammerman PS
影响因子：
6.7
作者：
Eichler, H-G;Bloechl-Daum, B.;Bauer, P.;Bretz, F.;Brown, J.;Hampson, L. V.;Honig, P.;Krams, M.;Leufkens, H.;Lim, R.;Lumpkin, M. M.;Murphy, M. J.;Pignatti, F.;Posch, M.;Schneeweiss, S.;Trusheim, M.;Koenig, F.
通讯作者：
Koenig, F.
影响因子：
39
作者：
Fralick, Michael;Kesselheim, Aaron S.;Schneeweiss, Sebastian
通讯作者：
Schneeweiss, Sebastian
影响因子：
37.8
作者：
Eichinger, Sabine;Heinze, Georg;Kyrle, Paul A.
通讯作者：
Kyrle, Paul A.