Effect of anesthesia carrier gas on in vivo circulation times of ultrasound microbubble contrast agents in rats.
Effect of anesthesia carrier gas on in vivo circulation times of ultrasound microbubble contrast agents in rats.
复制标题
DOI：
10.1002/cmmi.414
复制
发表时间：
2011-05
影响因子：
--
通讯作者：
Dayton, Paul A.
中科院分区：
文献类型：
--
作者：
Mullin, Lee;Gessner, Ryan;Kwan, James;Kaya, Mehmet;Borden, Mark A.;Dayton, Paul A.
微泡造影剂目前应用于各种临床和临床前超声成像研究。这些造影剂的治疗和诊断能力受到其短的体内寿命的限制，并且正在进行延长其循环时间的研究。在这份手稿中，观察结果来自一项对照实验，该实验旨在评价啮齿动物体内循环的脂质壳全氟化碳填充造影剂的循环时间差异，作为吸入麻醉载气的函数。在五只大鼠中观察了两种常用麻醉载气选择-纯氧和医用空气-的效果。测量了每只动物肾脏内造影剂的持续性，并比较了每只动物6次造影剂团注的氧气和空气麻醉载气。进行模拟以检查微泡行为与外部环境气体的变化。与呼吸纯氧相比，观察到呼吸医用空气的动物的造影剂循环时间在统计学上显著延长。模拟支持实验观察结果，并表明，增强对比度的持久性可以解释为减少通气/灌注不匹配和经典的扩散，其中氮气起着关键作用，有助于体积和稀释其他气体种类的微泡气体核心。结论：用医用空气代替氧气作为异氟醚麻醉的载气可以延长超声微泡造影剂的循环寿命。
Microbubble contrast agents are currently implemented in a variety of both clinical and preclinical ultrasound imaging studies. The therapeutic and diagnostic capabilities of these contrast agents are limited by their short in-vivo lifetimes, and research to lengthen their circulation times is ongoing. In this manuscript, observations are presented from a controlled experiment performed to evaluate differences in circulation times for lipid shelled perfluorocarbon-filled contrast agents circulating within rodents as a function of inhaled anesthesia carrier gas. The effects of two common anesthesia carrier gas selections - pure oxygen and medical air – were observed within five rats. Contrast agent persistence within the kidney was measured and compared for oxygen and air anesthesia carrier gas for six bolus contrast injections in each animal. Simulations were performed to examine microbubble behavior with changes in external environment gases. A statistically significant extension of contrast circulation time was observed for animals breathing medical air compared to breathing pure oxygen. Simulations support experimental observations and indicate that enhanced contrast persistence may be explained by reduced ventilation/perfusion mismatch and classical diffusion, in which nitrogen plays a key role by contributing to the volume and diluting other gas species in the microbubble gas core. Conclusion: Using medical air in place of oxygen as the carrier gas for isoflurane anesthesia can increase the circulation lifetime of ultrasound microbubble contrast agents.
登录
查看更多内容
影响因子：
4.6
作者：
Chatterjee, D;Jain, P;Sarkar, K
通讯作者：
Sarkar, K
DOI：
10.1109/tuffc.2004.1320741
发表时间：
2004-07-01
影响因子：
3.6
作者：
Shortencarier, MJ;Dayton, PA;Ferrara, KW
通讯作者：
Ferrara, KW
DOI：
10.1109/58.896136
发表时间：
2001-01-01
影响因子：
3.6
作者：
Chomas, JE;Dayton, P;Ferrara, KW
通讯作者：
Ferrara, KW
影响因子：
3.9
作者：
Borden, MA;Longo, ML
通讯作者：
Longo, ML
影响因子：
2.9
作者：
Hettiarachchi, Kanaka;Lee, Abraham P.;Zhang, Shirley;Feingold, Steven;Dayton, Paul A.
通讯作者：
Dayton, Paul A.