Increased body mass index is a risk factor for end-stage renal disease in the Chinese Singapore population.
Increased body mass index is a risk factor for end-stage renal disease in the Chinese Singapore population.
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体重指数增加是新加坡华人患终末期肾病的危险因素。
DOI：
10.1016/j.kint.2017.03.019
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发表时间：
2017-10
影响因子：
19.6
通讯作者：
Koh WP
中科院分区：
文献类型：
--
作者：
Lew QJ;Jafar TH;Talaei M;Jin A;Chow KY;Yuan JM;Koh WP
体重指数（BMI）和终末期肾病（ESRD）之间的关系被两种疾病相关的合并症所混淆。此外，低范围BMI的关联是有争议的。我们在新加坡华人健康研究中研究了这种关联，这是一项基于人群的前瞻性队列研究，从1993年到1998年招募了45-74岁的新加坡华人男性和女性。自我报告的体重、身高、生活方式因素、日常饮食和病史通过访谈者管理的问卷收集。突发ESRD病例通过与全国ESRD登记处的记录联系来确定。计算的Cox比例风险回归对潜在危险因素进行调整。经过平均15.5年的随访，确定了827例ESRD事件。与BMI在18.5 ~ 23 kg/m2之间的正常组相比，BMI在18.5、23 ~ 27.5和27.5 kg/m2及以上组的ESRD风险比和95%可信区间分别为0.54（0.37 ~ 0.79）、1.40（1.20 ~ 1.64）和2.13（1.74 ~ 2.59）。这种明显的趋势、线性、剂量依赖性关联仅存在于基线时无糖尿病、高血压、冠心病和中风史的患者中，但在有任何这些合并症的患者中不显著。因此，BMI本身是一般人群发生ESRD的一个危险因素，这种关联也存在于那些先前没有糖尿病、高血压、冠心病和中风的人群中。
The relationship between body mass index (BMI) and end stage renal disease (ESRD) is confounded by co-morbidities associated with both conditions. Furthermore, the association at low range BMI is controversial. We studied this association in the Singapore Chinese Health Study, a population-based prospective cohort that recruited Singaporean Chinese men and women 45–74 years of age from 1993 to 1998. Self-reported weight, height, lifestyle factors, usual diet and medical history were collected via an interviewer-administered questionnaire. Incident ESRD cases were identified via record linkage with the nationwide ESRD registry. The computed Cox proportional hazard regression was adjusted for potential risk factors. After an average follow up of 15.5 years, 827 incident ESRD cases were identified. Compared with a normal BMI of 18.5 to under 23 kg/m2, the hazard ratios and (95% confidence intervals) of ESRD risk for BMIs under 18.5, 23 to under 27.5, and 27.5 kg/m2 or more were 0.54 (0.37–0.79), 1.40 (1.20–1.64) and 2.13 (1.74–2.59), respectively. This significantly trended, linear, dose-dependent association was only present among those with no history of diabetes, hypertension, coronary heart disease and stroke at baseline, but not significantly among those with any of these co-morbidities. Thus, BMI itself is a risk factor for ESRD in the general population and this association is present in those without preexisting diabetes, hypertension, coronary heart disease and stroke.
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影响因子：
3
作者：
Anuurad, E;Shiwaku, K;Yamane, Y
通讯作者：
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