Pyroptosis: a new paradigm of cell death for fighting against cancer.
Pyroptosis: a new paradigm of cell death for fighting against cancer.
复制标题
细胞焦亡：对抗癌症的细胞死亡新范例
DOI：
10.1186/s13046-021-01959-x
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发表时间：
2021-05-03
期刊：
影响因子：
--
通讯作者：
Yi M
中科院分区：
文献类型：
--
作者：
Tan Y;Chen Q;Li X;Zeng Z;Xiong W;Li G;Li X;Yang J;Xiang B;Yi M
揭示细胞死亡的奥秘是过去几十年来生命科学最根本的进展之一。调节细胞死亡（regulatory cell death， RCD）或程序性细胞死亡（programmed cell death， PCD）不仅在胚胎发育过程中必不可少，而且在疾病特别是癌症的发生和发展中也起着重要作用。细胞免于死亡是癌症的特征之一。焦亡是一种炎症细胞死亡，通常由微生物感染引起，伴随着炎性小体的激活和促炎细胞因子白介素-1β (IL-1β)和白介素-18 （IL-18）的成熟。Gasdermin家族蛋白是焦亡的执行者。半胱天冬酶（caspase）或颗粒酶（gran酶）介导的气皮蛋白裂解产生的气皮蛋白的细胞毒性n端寡聚并在细胞膜上形成孔，导致IL-1β、IL-18的释放。焦亡具有抑瘤功能，引起抗肿瘤免疫反应。包括化疗、放疗、靶向治疗和免疫治疗在内的治疗方案可诱导肿瘤焦亡，从而增强局部和全身的抗肿瘤免疫。另一方面，正常细胞的焦亡归因于抗癌治疗的副作用。本文就焦亡的调控机制及焦亡的抑瘤作用作一综述。我们讨论了焦亡在肿瘤微环境重编程和抗肿瘤免疫恢复中的归属及其在癌症免疫治疗中的潜在应用。
Unraveling the mystery of cell death is one of the most fundamental progresses of life sciences during the past decades. Regulated cell death (RCD) or programmed cell death (PCD) is not only essential in embryonic development, but also plays an important role in the occurrence and progression of diseases, especially cancers. Escaping of cell death is one of hallmarks of cancer. Pyroptosis is an inflammatory cell death usually caused by microbial infection, accompanied by activation of inflammasomes and maturation of pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18). Gasdermin family proteins are the executors of pyroptosis. Cytotoxic N-terminal of gasdermins generated from caspases or granzymes proteases mediated cleavage of gasdermin proteins oligomerizes and forms pore across cell membrane, leading to release of IL-1β, IL-18. Pyroptosis exerts tumor suppression function and evokes anti-tumor immune responses. Therapeutic regimens, including chemotherapy, radiotherapy, targeted therapy and immune therapy, induce pyroptosis in cancer, which potentiate local and systemic anti-tumor immunity. On the other hand, pyroptosis of normal cells attributes to side effects of anti-cancer therapies. In this review, we focus on the regulatory mechanisms of pyroptosis and the tumor suppressive function of pyroptosis. We discuss the attribution of pyroptosis in reprogramming tumor microenvironments and restoration of anti-tumor immunity and its potential application in cancer immune therapy.
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影响因子：
4.6
作者：
Crittenden MR;Zebertavage L;Kramer G;Bambina S;Friedman D;Troesch V;Blair T;Baird JR;Alice A;Gough MJ
通讯作者：
Gough MJ
形成孔的蛋白质加油D可以调节白细胞介素-1的巨噬细胞分泌。
影响因子：
32.4
作者：
Evavold CL;Ruan J;Tan Y;Xia S;Wu H;Kagan JC
通讯作者：
Kagan JC
影响因子：
82.9
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
通讯作者：
Krummel MF
影响因子：
7.2
作者：
Golden EB;Frances D;Pellicciotta I;Demaria S;Helen Barcellos-Hoff M;Formenti SC
通讯作者：
Formenti SC
DOI：
10.1084/jem.20100050
发表时间：
2010-05-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allen IC;TeKippe EM;Woodford RM;Uronis JM;Holl EK;Rogers AB;Herfarth HH;Jobin C;Ting JP
通讯作者：
Ting JP