Cardiac progenitor cells and bone marrow-derived very small embryonic-like stem cells for cardiac repair after myocardial infarction.
Cardiac progenitor cells and bone marrow-derived very small embryonic-like stem cells for cardiac repair after myocardial infarction.
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DOI：
10.1253/circj.cj-09-0923
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Bolli R
中科院分区：
文献类型：
--
作者：
Tang XL;Rokosh DG;Guo Y;Bolli R
心肌梗死（MI）后心力衰竭仍然是全球发病率和死亡率最普遍的原因。虽然药物和干预策略对治疗有很大贡献，但鉴于总体疾病负担，迫切需要新的和上级治疗方式。基于干细胞的治疗可能是一种有前途的策略，导致心肌梗死后的心脏修复。在这方面，已经探索了一系列细胞类型，包括骨骼肌成肌细胞、骨髓（BM）源性干细胞、胚胎干细胞和最近的心脏祖细胞（CPC）。最近的研究表明，移植CPC或BM来源的非常小的胚胎样干细胞可以改善心脏功能，减轻心脏重塑，支持这些细胞用于心脏修复的潜在治疗用途。本报告总结了这些研究的当前数据，并讨论了这些细胞在开发临床相关的基于干细胞的心脏再生治疗策略中的潜在意义。
Heart failure after myocardial infarction (MI) continues to be the most prevalent cause of morbidity and mortality worldwide. Although pharmaceutical agents and interventional strategies have contributed greatly to therapy, new and superior treatment modalities are urgently needed given the overall disease burden. Stem cell-based therapy is potentially a promising strategy to lead to cardiac repair after MI. An array of cell types has been explored in this respect, including skeletal myoblasts, bone marrow (BM)-derived stem cells, embryonic stem cells, and more recently, cardiac progenitor cells (CPCs). Recently studies have obtained evidence that transplantation of CPCs or BM-derived very small embryonic-like stem cells can improve cardiac function and alleviate cardiac remodeling, supporting the potential therapeutic utility of these cells for cardiac repair. This report summarizes the current data from those studies and discusses the potential implication of these cells in developing clinically-relevant stem cell-based therapeutic strategies for cardiac regeneration.
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影响因子：
20.1
作者：
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通讯作者：
Anversa, P
影响因子：
64.8
作者：
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作者：
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DOI：
10.1084/jem.20070166
发表时间：
2007-12-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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