Structure, Function, and Allosteric Regulation of the 20S Proteasome by the 11S/PA28 Family of Proteasome Activators.
Structure, Function, and Allosteric Regulation of the 20S Proteasome by the 11S/PA28 Family of Proteasome Activators.
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DOI：
10.3390/biom13091326
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发表时间：
2023-08-29
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
蛋白酶体是一种复杂的多催化蛋白酶机制，协调维持细胞稳态所必需的蛋白质降解，其失调也是许多不同类型疾病的基础。它的功能受多种不同机制的调控，包括蛋白酶体激活剂（PAs）、衔接蛋白和翻译后修饰等多种因素。这篇综述通过一个独特的调节家族，11S， REGs或PA26/PA28，强调了蛋白酶体调节的独特特征。这个不依赖atp的家族，从变形虫到哺乳动物，具有共同的建筑结构；然而，它们的细胞生物学和蛋白质降解标准仍然难以捉摸。我们深入研究了它们的进化和细胞生物学，并全面对比了它们的结构和功能，强调了它们的调控机制和在蛋白质静止中更广泛的作用等尚未解决的问题。对这些过程的深入了解将阐明该调控家族在生物学和疾病中的作用，从而有助于提高治疗策略。
The proteasome, a complex multi-catalytic protease machinery, orchestrates the protein degradation essential for maintaining cellular homeostasis, and its dysregulation also underlies many different types of diseases. Its function is regulated by many different mechanisms that encompass various factors such as proteasome activators (PAs), adaptor proteins, and post-translational modifications. This review highlights the unique characteristics of proteasomal regulation through the lens of a distinct family of regulators, the 11S, REGs, or PA26/PA28. This ATP-independent family, spanning from amoebas to mammals, exhibits a common architectural structure; yet, their cellular biology and criteria for protein degradation remain mostly elusive. We delve into their evolution and cellular biology, and contrast their structure and function comprehensively, emphasizing the unanswered questions regarding their regulatory mechanisms and broader roles in proteostasis. A deeper understanding of these processes will illuminate the roles of this regulatory family in biology and disease, thus contributing to the advancement of therapeutic strategies.
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DOI：
10.1016/j.ijbiomac.2022.07.246
发表时间：
2022-08-10
影响因子：
8.2
作者：
Chen, Dan-Dan;Hao, Jia;Yun, Cai-Hong
通讯作者：
Yun, Cai-Hong
DOI：
10.1016/j.bbamcr.2013.02.028
发表时间：
2014-01
影响因子：
5.1
作者：
Bassermann, Florian;Eichner, Ruth;Pagano, Michele
通讯作者：
Pagano, Michele
影响因子：
64.8
作者：
DRISCOLL, J;BROWN, MG;MONACO, JJ
通讯作者：
MONACO, JJ
影响因子：
4.8
作者：
Brodsky, JL;Werner, ED;McCracken, AA
通讯作者：
McCracken, AA
影响因子：
4.5
作者：
Ben-Aroya S;Agmon N;Yuen K;Kwok T;McManus K;Kupiec M;Hieter P
通讯作者：
Hieter P