Non-Hodgkin's lymphomas and other malignancies in the acquired immune deficiency syndrome.
Non-Hodgkin's lymphomas and other malignancies in the acquired immune deficiency syndrome.
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非霍奇金淋巴瘤和获得性免疫缺陷综合征中的其他恶性肿瘤。
DOI：
10.5555/uri:pii:0093775487900285
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发表时间：
1987
影响因子：
4
通讯作者：
A. Levine
中科院分区：
文献类型：
--
作者：
A. Levine
获得性免疫缺陷综合征（AIDS）患者中约95%的肿瘤是卡波西肉瘤或非霍奇金恶性淋巴瘤。卡波西肉瘤是迄今为止发现的最常见的恶性肿瘤，尽管也有报道称主要为高级别B细胞恶性淋巴瘤的发病率显著增加。有证据表明EB病毒（EBV）与淋巴瘤的高发病率之间存在相关性，对此最合理的解释是EBV能够引起持续的B细胞增殖。还研究了其他药物作为诱导AIDS患者B细胞淋巴瘤或卡波西肉瘤的潜在辅助因子，包括巨细胞病毒和亚硝酸盐。然而，它们的确切作用仍然是推测性的，需要进一步研究。目前尚无证据表明人类免疫缺陷病毒（HIV）感染患者与霍奇金病之间存在因果关系，也没有流行病学数据表明霍奇金病与艾滋病有关。在HIV感染者中描述的其他肿瘤包括泄殖腔源性肛门直肠癌和头颈口腔鳞状细胞癌，但目前没有流行病学证据证明这些癌症是AIDS谱的一部分。尽管使用标准化疗方案可以实现完全缓解，但这些缓解在大多数患者中并不持久。
Approximately 95% of neoplasms in acquired immune deficiency syndrome (AIDS) patients are either Kaposi's sarcoma or non-Hodgkin's malignant lymphoma. Kaposi's sarcoma is by far the most prevalent malignancy found, although a marked increase in the incidence of predominantly high-grade B cell malignant lymphomas has also been reported. There is evidence suggesting a correlation between Epstein-Barr virus (EBV) and the high incidence of lymphomas, and the most plausible explanation for this is the ability for EBV to cause ongoing B cell proliferation. Other agents have also been studied as potential cofactors in the induction of B cell lymphomas or Kaposi's sarcoma in AIDS patients, including cytomegalovirus and nitrites. Their precise roles remain speculative, however, and further study is needed. At this time there is no evidence of a cause-and-effect relationship between human immunodeficiency virus (HIV)-infected patients and Hodgkin's disease, nor is there epidemiologic data to suggest that Hodgkin's disease is related to AIDS. Other neoplasms that have been described in HIV-infected individuals include cloacogenic anorectal carcinoma and squamous-cell carcinoma of the head, neck, and oral cavity, but there is currently no epidemiologic evidence to prove that these cancers are part of the spectrum of AIDS. Although complete remission may be achieved using standard chemotherapeutic regimens, these remissions are not durable in the majority of patients.
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心脏移植受者淋巴增殖性病变的单克隆性。
DOI：
10.1056/nejm198402233100801
发表时间：
1984
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cleary,ML;Warnke,R;Sklar,J
通讯作者：
Sklar,J
使用克隆探针检测肿瘤和淋巴增殖性疾病患者组织中的 Epstein-Barr 病毒 DNA。
DOI：
10.1093/infdis/148.6.967
发表时间：
1983
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Andiman,W;Gradoville,L;Heston,L;Neydorff,R;Savage,ME;Kitchingman,G;Shedd,D;Miller,G
通讯作者：
Miller,G
艾滋病和霍奇金病。
影响因子：
--
作者：
Schoeppel,SL;Hoppe,RT;Dorfman,RF;Horning,SJ;Chew,TG;Weiss,LM;Collier,AC
通讯作者：
Collier,AC
免疫功能低下的同性恋男性中的侵袭性非霍奇金淋巴瘤。
影响因子：
20.3
作者：
Kalter,SP;Riggs,SA;Cabanillas,F;Butler,JJ;Hagemeister,FB;Mansell,PW;Newell,GR;Velasquez,WS;Salvador,P;Barlogie,B
通讯作者：
Barlogie,B
特定易位是患有获得性免疫缺陷综合征的同性恋男性的伯基特样淋巴瘤的特征。
影响因子：
20.3
作者：
Chaganti,RS;Jhanwar,SC;Koziner,B;Arlin,Z;Mertelsmann,R;Clarkson,BD
通讯作者：
Clarkson,BD