Malnutrition, a new inducer for arterial calcification in hemodialysis patients?
Malnutrition, a new inducer for arterial calcification in hemodialysis patients?
复制标题
营养不良是血液透析患者动脉钙化的新诱因？
DOI：
10.1186/1479-5876-11-66
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发表时间：
2013-03-18
影响因子：
7.4
通讯作者：
Huang H
中科院分区：
文献类型：
--
作者：
Zhang K;Cheng G;Cai X;Chen J;Jiang Y;Wang T;Wang J;Huang H
动脉钙化是血液透析患者重要的心血管危险因素。动脉钙化过程涉及一系列因素；然而，营养不良与动脉钙化之间的关系仍不清楚。 68 名血液透析患者参与了这项研究。使用改良定量主观总体评估（MQSGA）评估营养状况。测定相关血清生化参数。动静脉内瘘手术时采集桡动脉样本。苏木精/伊红染色观察动脉结构，茜素红染色观察钙化沉积并对钙化程度进行分级。采用免疫组化和Western blot方法检测骨形态发生蛋白2（BMP2）和基质Gla蛋白（MGP）的表达。 66.18%的血液透析患者存在营养不良。血液透析患者钙化沉积主要位于桡动脉内层，钙化区BMP2和MGP表达均升高。血清白蛋白水平与钙化评分、BMP2、MGP表达呈负相关。而MQSGA评分、血清磷、钙×磷乘积与钙化评分、BMP2、MGP表达呈正相关。营养不良在血液透析患者中普遍存在，并且与动脉钙化以及钙化的桡动脉中 BMP2 和 MGP 的表达相关。营养不良可能是血液透析患者动脉钙化的新诱因。
Arterial calcification is a significant cardiovascular risk factor in hemodialysis patients. A series of factors are involved in the process of arterial calcification; however, the relationship between malnutrition and arterial calcification is still unclear. 68 hemodialysis patients were enrolled in this study. Nutrition status was evaluated using modified quantitative subjective global assessment (MQSGA). Related serum biochemical parameters were measured. And the radial artery samples were collected during the arteriovenous fistula surgeries. Hematoxylin/eosin stain was used to observe the arterial structures while Alizarin red stain to observe calcified depositions and classify calcified degree. The expressions of bone morphogenetic protein 2 (BMP2) and matrix Gla protein (MGP) were detected by immunohistochemistry and western blot methods. 66.18% hemodialysis patients were malnutrition. In hemodialysis patients, the calcified depositions were mainly located in the medial layer of the radial arteries and the expressions of BMP2 and MGP were both increased in the calcified areas. The levels of serum albumin were negatively associated with calcification score and the expressions of BMP2 and MGP. While MQSGA score, serum phosphorus and calcium × phosphorus product showed positive relationships with calcification score and the expressions of BMP2 and MGP. Malnutrition is prevalent in hemodialysis patients and is associated with arterial calcification and the expressions of BMP2 and MGP in calcified radial arteries. Malnutrition may be a new inducer candidate for arterial calcification in hemodialysis patients.
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期刊：
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