Comparison of brain transcriptome of the greater horseshoe bats (Rhinolophus ferrumequinum) in active and torpid episodes.
Comparison of brain transcriptome of the greater horseshoe bats (Rhinolophus ferrumequinum) in active and torpid episodes.
复制标题
大马蹄蝠（Rhinolophus ferrumequinum）活跃和迟钝状态下大脑转录组的比较。
DOI：
10.1371/journal.pone.0107746
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Lei M;Dong D;Mu S;Pan YH;Zhang S
冬眠是异温哺乳动物在恶劣环境中生存的一种节能策略。大菊头蝠（Rhinolophus ferrumequinum）在冬眠季节可以冬眠很长一段时间。然而，全球的基因表达变化之间的冬眠和非冬眠季节在大马蹄蝙蝠仍然在很大程度上是未知的。我们在此报告了一个全面的调查差异基因表达的大脑之间的冬季冬眠和夏季活跃的大马蹄蝙蝠使用新一代测序技术。总共生成了90，314，174个读数，我们鉴定了1，573个在活跃状态和迟钝状态之间差异表达的基因。有趣的是，我们发现差异表达的基因在某些GO类别（如代谢抑制，细胞应激反应和氧化应激）中过度表达，这表明神经保护策略可能在冬眠控制机制中发挥重要作用。我们的研究结果确定了大马蹄蝙蝠的大脑组织在夏季活跃和冬季冬眠状态之间的基因表达差异的程度，并为蝙蝠冬眠的适应机制提供了全面的见解。
Hibernation is an energy-saving strategy which is widely adopted by heterothermic mammals to survive in the harsh environment. The greater horseshoe bat (Rhinolophus ferrumequinum) can hibernate for a long period in the hibernation season. However, the global gene expression changes between hibernation and non-hibernation season in the greater horseshoe bat remain largely unknown. We herein reported a comprehensive survey of differential gene expression in the brain between winter hibernating and summer active greater horseshoe bats using next-generation sequencing technology. A total of 90,314,174 reads were generated and we identified 1,573 differentially expressed genes between active and torpid states. Interestingly, we found that differentially expressed genes are over-represented in some GO categories (such as metabolic suppression, cellular stress responses and oxidative stress), which suggests neuroprotective strategies might play an important role in hibernation control mechanisms. Our results determined to what extent the brain tissue of the greater horseshoe bats differ in gene expression between summer active and winter hibernating states and provided comprehensive insights into the adaptive mechanisms of bat hibernation.
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DOI：
10.1196/annals.1391.032
发表时间：
2007-01-01
期刊：
STRESS RESPONSES IN BIOLOGY AND MEDICINE
影响因子：
--
作者：
Brown, Ian R.
通讯作者：
Brown, Ian R.
影响因子：
3.7
作者：
Hampton M;Melvin RG;Kendall AH;Kirkpatrick BR;Peterson N;Andrews MT
通讯作者：
Andrews MT
影响因子：
4.6
作者：
Fedorov, Vadim B.;Goropashnaya, Anna V.;Barnes, Brian M.
通讯作者：
Barnes, Brian M.
影响因子：
6.3
作者：
FRERICHS, KU;KENNEDY, C;HALLENBECK, JM
通讯作者：
HALLENBECK, JM
影响因子：
14.8
作者：
Huang, Da Wei;Sherman, Brad T.;Lempicki, Richard A.
通讯作者：
Lempicki, Richard A.