Validating and assessing the sensitivity of the Health Assessment Questionnaire-Disability Index-derived Short Form-6D in patients with early aggressive rheumatoid arthritis.
Validating and assessing the sensitivity of the Health Assessment Questionnaire-Disability Index-derived Short Form-6D in patients with early aggressive rheumatoid arthritis.
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DOI：
10.3899/jrheum.080959
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Western Consortium of Practicing Rheumatologists
中科院分区：
文献类型：
--
作者：
Amjadi SS;Maranian PM;Paulus HE;Kaplan RM;Ranganath VK;Furst DE;Khanna PP;Khanna D;Western Consortium of Practicing Rheumatologists
新的方法可以将健康评估中的残疾指数的分数转化为偏好/效用分数。我们评估了HAQ-DI衍生SF-6D评分的结构效度，并评估了其对早期侵袭性类风湿关节炎（RA）患者6个月和12个月随访期间变化的反应性。参与RA观察性研究的患者（N=277）在基线、6个月和12个月时完成了症状和HAQ-DI的自我报告测量。使用临床数据评估总Sharp评分、C反应蛋白和红细胞沉降率。通过使用斯皮尔曼相关系数检查SF-6D评分与患者报告和临床测量之间的关联来评估结构效度。使用患者和医生对疾病的评估作为临床锚点，评估SF-6D对变化的反应性。使用SF-6D效应量（ES）计算反应性的大小。基线、6个月和12个月随访访视时的平均SF-6D评分分别为0.690、0.720和0.723。基线患者报告的测量值与基线SF-6D具有中度至高度相关性（r：0.43至0.52）;而临床测量值与SF-6D具有可忽略至低度相关性（r：0.001至0.32）。对于被认为有改善的组，ES为中度（ES：0.63-0.75），但对于那些没有改善的组，ES为可忽略到小（ES：0.13-0.46）。我们的数据支持HAQ-DI得出的SF-6D评分在早期RA队列中的有效性和反应性。这些结果支持在RA队列和缺乏基于偏好的测量的临床试验中使用HAQ-DI衍生的SF-6D。
New methodologies allow the scores for the Health Assessment Questionnaire-Disability Index (HAQ-DI) to be translated into preferences/ utility scores. We evaluated the construct validity of the HAQ-DI derived SF-6D score and assessed its responsiveness to change over 6- and 12-month follow-up periods in patients with early aggressive rheumatoid arthritis (RA). Patients (N=277) participating in an RA observational study completed self-reported measures of symptoms and the HAQ-DI at baseline, 6 and 12 months. Total Sharp scores, C-reactive protein and erythrocyte sedimentation rate were assessed using clinical data. Construct validity was assessed by examining the association between SF-6D score and patient-reported and clinical measures using Spearman correlation coefficients. The responsiveness of SF-6D to change was assessed using patient and physician assessments of the disease as clinical anchors. The magnitude of responsiveness was calculated using SF-6D effect size (ES). Mean SF-6D scores were 0.690, 0.720, and 0.723 at baseline, 6, and 12-month follow-up visits, respectively. Baseline patient-reported measures had moderate-to-high correlations with baseline SF-6D (r: 0.43 to 0.52); whereas clinical measures had negligible-to-low correlations with SF-6D (r: 0.001 to 0.32). ES was moderate for the groups that were deemed to have improved (ES: 0.63–0.75) but negligible-to-small for those who did not (ES: 0.13–0.46). Our data supports the validity and responsiveness of the HAQ-DI derived SF-6D score in an early RA cohort. These results support the use of HAQ-DI derived SF-6D in RA cohorts and clinical trials lacking preference-based measures.
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影响因子：
3.5
作者：
Walters, SJ;Brazier, JE
通讯作者：
Brazier, JE
影响因子：
4.5
作者：
Brazier, JE;Kolotkin, RL;Williams, GR
通讯作者：
Williams, GR
DOI：
10.1007/bf00435438
发表时间：
1992-02-01
期刊：
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
影响因子：
--
作者：
Hays, R D;Hadorn, D
通讯作者：
Hadorn, D
影响因子：
--
作者：
Khanna, Dinesh;Yan, Xiaohong;Clements, Philip J.
通讯作者：
Clements, Philip J.
影响因子：
5
作者：
Strand, Vibeke;Kelman, Ariella
通讯作者：
Kelman, Ariella