Transforming growth factor α levels in pancreatic fluid.
Transforming growth factor α levels in pancreatic fluid.
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胰液中转化生长因子α的水平。
DOI：
10.1097/mpa.0b013e3181f94d2a
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发表时间：
2011
期刊：
影响因子：
2.9
通讯作者：
Schmidt,ChristianMax
中科院分区：
文献类型：
--
作者：
Doyle,CourtneyJ;Agaram,NarasimhanP;Yip-Schneider,MicheleT;Schmidt,ChristianMax
目的：探讨胰液（PF）中转化生长因子α（TGF-α）水平对胰腺导管内乳头状黏液性肿瘤（IPMN）与胰腺其他囊性病变的诊断价值。采用酶联免疫吸附试验（ELISA）检测胰腺液TGF-α水平。TGF-α免疫组化分析了58例胰腺疾病患者的69份液体样本：IPMN（26例），浆液性囊腺瘤（6例），粘液性囊性肿瘤（9例），假性囊肿（5例），非IPMN相关的胰腺导管腺癌（6例）和Oddi括约肌功能障碍（6例）。不同类型和不同发育不良程度的IPMN间PF-TGF-α水平差异无统计学意义。然而，在所有检查的诊断中，只有IPMN显示PF-TGF-α水平大于95 pg/mL。在低级别IPMN标本，TGF-α免疫组化与酶联免疫吸附测定levels.Conclusions：平均PF-TGF-α水平是没有显着不同的IPMN病变相比，与其他囊性胰腺病变，胰腺导管腺癌，或Oddi括约肌功能障碍。但PF-TGF-α水平高于95 pg/mL可能有助于诊断IPMN。这一主张需要前瞻性验证。
Objective:To determine if the level of transforming growth factor α (TGF-α) in the pancreatic fluid (PF) can diagnose intraductal papillary mucinous neoplasm (IPMN) versus other cystic lesions of the pancreas in patients.Methods:Pancreatic fluid was prospectively obtained from patients during routine endoscopy and/or operation at Indiana University Hospital. Pancreatic fluid TGF-α levels were analyzed by enzyme-linked immunosorbent assay. Intraductal papillary mucinous neoplasm tissue was also analyzed by TGF-α immunohistochemistry.Results:Sixty-nine fluid samples from 58 patients with the following pathologically confirmed pancreatic disorders were analyzed: IPMN (26 patients), serous cystadenoma (6), mucinous cystic neoplasm (9), pseudocysts (5), non-IPMN-associated pancreatic ductal adenocarcinoma (6), and sphincter of Oddi dysfunction (6). There was no significant difference between the mean PF-TGF-α levels in each category or between different dysplastic grades of IPMN. However, of all the diagnoses examined, only IPMN demonstrated PF-TGF-α levels greater than 95 pg/mL. In low-grade IPMN specimens, TGF-α immunohistochemistry correlated with enzyme-linked immunosorbent assay levels.Conclusions:The mean PF-TGF-α levels are not significantly different in IPMN lesions compared with those in other cystic pancreatic lesions, pancreatic ductal adenocarcinoma, or sphincter of Oddi dysfunction. However, PF-TGF-α levels more than 95 pg/mL may be useful in diagnosing IPMN. This assertion requires prospective validation.
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