Can we achieve better trial recruitment by presenting patient information through multimedia? Meta-analysis of 'studies within a trial' (SWATs).
Can we achieve better trial recruitment by presenting patient information through multimedia? Meta-analysis of 'studies within a trial' (SWATs).
复制标题
DOI：
10.1186/s12916-023-03081-5
复制
发表时间：
2023-11-08
期刊：
影响因子：
9.3
通讯作者：
Bower, Peter
中科院分区：
文献类型：
--
作者：
Madurasinghe, Vichithranie W.;Knapp, Peter;Eldridge, Sandra;Collier, David;Treweek, Shaun;Rick, Jo;Graffy, Jonathan;Parker, Adwoa;Salisbury, Chris;Torgerson, David;Jolly, Kate;Sidhu, Manbinder S.;Fife-Schaw, Christopher;Hull, Mark A.;Sprange, Kirsty;Brettell, Elizabeth;Bhandari, Sunil;Montgomery, Alan;Bower, Peter
关键词：
人们需要高质量的信息来决定是否参与研究。仅以书面形式提供信息是常规做法，但可能不是最有效和可接受的办法。我们开发了一个结构，使用多媒体，其中包括通用和试验特定的内容的信息演示。我们的目标是在多个正在进行的试验中嵌入“试验中的研究”（SWAT），以测试患者信息的多媒体呈现是否会导致更好的招募率。五项试验包括一个SWAT，并随机分配他们的参与者接受多媒体演示和标准信息，或仅接受标准书面信息。我们收集了关于试验招募、接受和保留的数据，并使用随机效应荟萃分析对汇总结果进行了分析，主要结局定义为邀请参加后随机分配的参与者比例。5项SWAT提供了随机化受试者比例的主要结局数据。多媒体与书面信息在招募率方面几乎没有差异（合并比值比= 0.96，95%CI：0.79至1.17，p值= 0.671，I2 = 0%）。对其他结局无影响。多媒体与书面信息并没有提高审判招募率。ISRCTN 71952900、ISRCTN 06710391、ISRCTN 17160087、ISRCTN 05926847、ISRCTN 62869767。在线版本包含补充材料，可通过10.1186/s12916-023-03081-5获得。
People need high-quality information to make decisions about research participation. Providing information in written format alone is conventional but may not be the most effective and acceptable approach. We developed a structure for the presentation of information using multimedia which included generic and trial-specific content. Our aim was to embed ‘Studies Within A Trial’ (SWATs) across multiple ongoing trials to test whether multimedia presentation of patient information led to better rates of recruitment. Five trials included a SWAT and randomised their participants to receive a multimedia presentation alongside standard information, or standard written information alone. We collected data on trial recruitment, acceptance and retention and analysed the pooled results using random effects meta-analysis, with the primary outcome defined as the proportion of participants randomised following an invitation to take part. Five SWATs provided data on the primary outcome of proportion of participants randomised. Multimedia alongside written information results in little or no difference in recruitment rates (pooled odds ratio = 0.96, 95% CI: 0.79 to 1.17, p-value = 0.671, I2 = 0%). There was no effect on any other outcomes. Multimedia alongside written information did not improve trial recruitment rates. ISRCTN71952900, ISRCTN 06710391, ISRCTN 17160087, ISRCTN05926847, ISRCTN62869767. The online version contains supplementary material available at 10.1186/s12916-023-03081-5.
登录
查看更多内容
影响因子：
5.2
作者：
Tait AR;Voepel-Lewis T;Levine R
通讯作者：
Levine R
影响因子：
2.5
作者：
Fife-Schaw, Chris;de Lusignan, Simon;O'Neill, Mark
通讯作者：
O'Neill, Mark
影响因子：
2.5
作者：
McDonald, Alison M.;Knight, Rosemary C.;Snowdon, Claire
通讯作者：
Snowdon, Claire
影响因子：
2.5
作者：
Rick, Jo;Graffy, Jonathan;Bower, Peter
通讯作者：
Bower, Peter
影响因子：
2.9
作者：
Treweek S;Lockhart P;Pitkethly M;Cook JA;Kjeldstrøm M;Johansen M;Taskila TK;Sullivan FM;Wilson S;Jackson C;Jones R;Mitchell ED
通讯作者：
Mitchell ED