Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis.
Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis.
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DOI：
10.1136/bmjopen-2012-002360
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发表时间：
2013
期刊：
影响因子：
2.9
通讯作者：
Mitchell ED
中科院分区：
文献类型：
--
作者：
Treweek S;Lockhart P;Pitkethly M;Cook JA;Kjeldstrøm M;Johansen M;Taskila TK;Sullivan FM;Wilson S;Jackson C;Jones R;Mitchell ED
本综述是之前发表在科克伦系统综述数据库2010年第4期的一篇科克伦综述的节略版本，文章编号：MR 000013 DOI：10.1002/14651858.MR000013.pub5（参见www.thecochranelibrary.com获取信息）。科克伦综述会随着新证据的出现和反馈而定期更新，最新版本的综述应查阅科克伦系统综述数据库。确定旨在改善随机对照试验招募的干预措施，并量化其对试验参与的影响。系统评价。科克伦方法学审查小组在科克伦图书馆、MEDLINE、EMBASE、ERIC、科学引文索引、社会科学引文索引、C2-SPECTR、国家研究注册和PubMed中进行了专业注册。大多数检索是在2010年之前进行的;没有语言限制。随机和准随机对照试验，包括那些招募到假设研究。保留策略的研究，研究如何增加问卷调查的答复或评估使用的激励措施，为临床医生被排除在外。研究人群包括任何潜在的试验参与者（例如，患者、临床医生和公众），或负责试验招募的个人或个人组（例如，临床医生、研究人员和招募中心）。两位作者独立筛选了已识别的研究的合格性。纳入了45项试验，超过43000名受试者。一些干预措施在增加征聘方面是有效的：向未答复者打电话提醒（风险比（RR）1.66，95% CI 1.03 - 2.46;两项研究，1058例受试者），使用选择退出而非选择加入程序联系潜在受试者（RR 1.39，95% CI 1.06至1.84; 1项研究，152名受试者）和开放设计，其中受试者知道他们在试验中接受的治疗（RR 1.22，95% CI 1.09至1.36; 2项研究，4833名受试者）。然而，许多其他战略的效果不太清楚，包括使用视频提供审判信息和针对招聘人员的干预措施。有一些很有希望的战略可以增加试验招募人数，但必须仔细考虑一些方法，如开放试验设计和选择退出战略，因为它们的使用也可能带来方法或伦理方面的挑战。对于来自假设试验的结果，包括与使用金钱奖励有关的结果的适用性，仍然存在问题，而且在针对招聘人员的有效战略方面存在明显的知识差距。
This review is an abridged version of a Cochrane Review previously published in the Cochrane Database of Systematic Reviews 2010, Issue 4, Art. No.: MR000013 DOI: 10.1002/14651858.MR000013.pub5 (see www.thecochranelibrary.com for information). Cochrane Reviews are regularly updated as new evidence emerges and in response to feedback, and Cochrane Database of Systematic Reviews should be consulted for the most recent version of the review. To identify interventions designed to improve recruitment to randomised controlled trials, and to quantify their effect on trial participation. Systematic review. The Cochrane Methodology Review Group Specialised Register in the Cochrane Library, MEDLINE, EMBASE, ERIC, Science Citation Index, Social Sciences Citation Index, C2-SPECTR, the National Research Register and PubMed. Most searches were undertaken up to 2010; no language restrictions were applied. Randomised and quasi-randomised controlled trials, including those recruiting to hypothetical studies. Studies on retention strategies, examining ways to increase questionnaire response or evaluating the use of incentives for clinicians were excluded. The study population included any potential trial participant (eg, patient, clinician and member of the public), or individual or group of individuals responsible for trial recruitment (eg, clinicians, researchers and recruitment sites). Two authors independently screened identified studies for eligibility. 45 trials with over 43 000 participants were included. Some interventions were effective in increasing recruitment: telephone reminders to non-respondents (risk ratio (RR) 1.66, 95% CI 1.03 to 2.46; two studies, 1058 participants), use of opt-out rather than opt-in procedures for contacting potential participants (RR 1.39, 95% CI 1.06 to 1.84; one study, 152 participants) and open designs where participants know which treatment they are receiving in the trial (RR 1.22, 95% CI 1.09 to 1.36; two studies, 4833 participants). However, the effect of many other strategies is less clear, including the use of video to provide trial information and interventions aimed at recruiters. There are promising strategies for increasing recruitment to trials, but some methods, such as open-trial designs and opt-out strategies, must be considered carefully as their use may also present methodological or ethical challenges. Questions remain as to the applicability of results originating from hypothetical trials, including those relating to the use of monetary incentives, and there is a clear knowledge gap with regard to effective strategies aimed at recruiters.
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