Nigral volumetric and microstructural measures in individuals with scans without evidence of dopaminergic deficit.
Nigral volumetric and microstructural measures in individuals with scans without evidence of dopaminergic deficit.
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DOI：
10.3389/fnins.2022.1048945
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发表时间：
2022
影响因子：
4.3
通讯作者：
Huddleston, Daniel E.
中科院分区：
文献类型：
--
作者：
Langley, Jason;Hwang, Kristy S.;Hu, Xiaoping P.;Huddleston, Daniel E.
关键词：
纹状体多巴胺转运体(DAT)成像使用123I-碘-氟烷单光子正电子发射计算机断层扫描(DATSCAN，GE)，在新诊断的帕金森病(PD)受试者中，有20%的人在临床研究中进行了扫描，但没有多巴胺能缺陷的证据。这些人符合帕金森病的诊断标准，但在临床上没有预期的进展，而且他们也不被认为患有神经退行性帕金森综合症。因此，将SWEDD参与者纳入PD生物标记物研究或治疗试验可能会导致他们失败。DaTcan可以识别SWEDD患者，但它价格昂贵，而且不能广泛使用；需要一种替代的成像方法。在这里，我们评估神经黑色素敏感、铁敏感和黑质致密部弥散对比(SNPC)的使用来区分SWEDD和PD患者。SWEDD、PD和对照受试者的神经黑色素敏感、铁敏感和弥散成像数据从帕金森进展标志物倡议(PPMI)数据库下载。测量每个参与者的SNPC容量、SNPC铁(R2)和SNPC游离水(FW)。PD组SNPC体积明显小于SWEDD组(P<；10-3)和对照组(P<；10-3)。PD组SNPC FW较对照组升高(P=0.017)。在SNPC R2中没有观察到组间差异。总而言之，SWEDD组的黑质体积和FW与对照组相似，而PD组的黑质体积减少，FW增加。这些结果表明，这些MRI措施应作为评估黑质纹状体系统的DATcan的一种经济有效的替代方法。
Striatal dopamine transporter (DAT) imaging using 123I-ioflupane single photon positron emitted computed tomography (SPECT) (DaTScan, GE) identifies 5−20% of newly diagnosed Parkinson’s disease (PD) subjects enrolling in clinical studies to have scans without evidence of dopaminergic deficit (SWEDD). These individuals meet diagnostic criteria for PD, but do not clinically progress as expected, and they are not believed to have neurodegenerative Parkinsonism. Inclusion of SWEDD participants in PD biomarker studies or therapeutic trials may therefore cause them to fail. DaTScan can identify SWEDD individuals, but it is expensive and not widely available; an alternative imaging approach is needed. Here, we evaluate the use of neuromelanin-sensitive, iron-sensitive, and diffusion contrasts in substantia nigra pars compacta (SNpc) to differentiate SWEDD from PD individuals. Neuromelanin-sensitive, iron-sensitive, and diffusion imaging data for SWEDD, PD, and control subjects were downloaded from the Parkinson’s progression markers initiative (PPMI) database. SNpc volume, SNpc iron (R2), and SNpc free water (FW) were measured for each participant. Significantly smaller SNpc volume was seen in PD as compared to SWEDD (P < 10–3) and control (P < 10–3) subjects. SNpc FW was elevated in the PD group relative to controls (P = 0.017). No group difference was observed in SNpc R2. In conclusion, nigral volume and FW in the SWEDD group were similar to that of controls, while a reduction in nigral volume and increased FW were observed in the PD group relative to SWEDD and control participants. These results suggest that these MRI measures should be explored as a cost-effective alternative to DaTScan for evaluation of the nigrostriatal system.
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DOI：
10.1093/brain/awab191
发表时间：
2021-11-29
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Biondetti E;Santin MD;Valabrègue R;Mangone G;Gaurav R;Pyatigorskaya N;Hutchison M;Yahia-Cherif L;Villain N;Habert MO;Arnulf I;Leu-Semenescu S;Dodet P;Vila M;Corvol JC;Vidailhet M;Lehéricy S
通讯作者：
Lehéricy S
影响因子：
3.5
作者：
Garyfallidis E;Brett M;Amirbekian B;Rokem A;van der Walt S;Descoteaux M;Nimmo-Smith I;Dipy Contributors
通讯作者：
Dipy Contributors
影响因子：
4.8
作者：
Jin Z;Wang Y;Jokar M;Li Y;Cheng Z;Liu Y;Tang R;Shi X;Zhang Y;Min J;Liu F;He N;Yan F;Haacke EM
通讯作者：
Haacke EM
DOI：
10.1093/brain/awx146
发表时间：
2017-08-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Burciu RG;Ofori E;Archer DB;Wu SS;Pasternak O;McFarland NR;Okun MS;Vaillancourt DE
通讯作者：
Vaillancourt DE
影响因子：
2.8
作者：
Kitao, Shinichiro;Matsusue, Eiji;Ogawa, Toshihide
通讯作者：
Ogawa, Toshihide