Chromium dinicocysteinate supplementation can lower blood glucose, CRP, MCP-1, ICAM-1, creatinine, apparently mediated by elevated blood vitamin C and adiponectin and inhibition of NFkappaB, Akt, and Glut-2 in livers of zucker diabetic fatty rats.
Chromium dinicocysteinate supplementation can lower blood glucose, CRP, MCP-1, ICAM-1, creatinine, apparently mediated by elevated blood vitamin C and adiponectin and inhibition of NFkappaB, Akt, and Glut-2 in livers of zucker diabetic fatty rats.
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DOI：
10.1002/mnfr.200900177
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发表时间：
2010-09
影响因子：
5.2
通讯作者：
Bull, Rebeca
中科院分区：
文献类型：
--
作者：
Jain, Sushil K.;Croad, Jennifer L.;Velusamy, Thirunavukkarasu;Rains, Justin L.;Bull, Rebeca
Chromium and cysteine supplementation can improve glucose metabolism in animal studies. This study examined the hypothesis that a cysteinate complex of chromium is significantly beneficial than either of them in lowering blood glucose and vascular inflammation markers in ZDF rats. Starting at the age of 6 wks, ZDF rats were supplemented orally (daily gavages for 8 more wks) with saline-placebo (D) or chromium (400µg Cr/KgBW) as chromium-dinicocysteinate (CDNC), chromium-dinicotinate (CDN), or chromium-picolinate (CP) or equimolar L-cysteine (LC, img/Kg BW), and fed Purina 5008 diet for 8 wks. ZDF rats of 6 wks age before any supplementations and onset of diabetes were considered as baseline (BL). D rats showed elevated levels of fasting blood glucose, HbA1, CRP, MCP-1, ICAM-1 and oxidative stress (LP) and lower adiponectin and vitamin C, when compared to BL rats. In comparison to D group, CDNC group had significantly lower blood glucose, HbA1, CRP, MCP-1, ICAM-1 and LP and increased vitamin C and adiponectin levels. CDN, CP or LC showed significantly less or no effect on these biomarkers. Only CDNC lowered blood creatinine levels in comparison to D. While CDN and CP had no effect, activation of NFkB, Akt and GLUT-2 levels were decreased, IRS-1 activation increased in livers of CDNC-rats. CDNC effect on glycemia, NFkB, Akt and IRS-1 in liver was significantly greater compared with LC. Blood chromium levels did not differ between Cr-groups. Exogenous vitamin C supplementation significantly inhibited MCP-1 secretion in U937 monocytes cultured in high-glucose-medium. CDNC is a potent hypoglycemic compound with anti-inflammatory activity apparently mediated by elevated blood vitamin C and adiponectin and inhibition of NFkB, Akt, and Glut-2 and increased IRS-1 activation in livers of type 2 diabetic rats.
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影响因子：
4.5
作者：
Chui, Michael Herman;Greenwood, Carol E.
通讯作者：
Greenwood, Carol E.
影响因子：
9.8
作者：
Godsland, Ian F.;Johnston, Desmond G.
通讯作者：
Johnston, Desmond G.
影响因子：
5.3
作者：
JIALAL, I;VEGA, GL;GRUNDY, SM
通讯作者：
GRUNDY, SM
DOI：
10.1098/rstb.2005.1770
发表时间：
2005-12-29
影响因子：
6.3
作者：
Dröge, W
通讯作者：
Dröge, W
影响因子：
4.8
作者：
Meng, FY;Liu, L;D'Mello, SR
通讯作者：
D'Mello, SR