Dissociated and Reconstituted Cartilage Microparticles in Densified Collagen Induce Local hMSC Differentiation.

Dissociated and Reconstituted Cartilage Microparticles in Densified Collagen Induce Local hMSC Differentiation.
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DOI:
10.1002/adfm.201601877
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发表时间:
2016-08-09
影响因子:
19
通讯作者:
Neu CP Prof
Neu CP Prof
中科院分区:
材料科学1区
文献类型:
--
作者:
Novak T;Seelbinder B;Twitchell CM;Voytik-Harbin SL Prof;Neu CP Prof

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Decellularized cartilage microparticles, and all associated native signals, are delivered to hMSC populations in a dense, type I collagen matrix. Hybrid usage of native tissue signals and the engineering control of collagen matrices show the ability to induce local infiltration and differentiation of hMSCs. Additionally, the solid cartilage microparticles inhibit bulk cell-mediated contraction of the composite.
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