Harnessing the power of metabolism for seizure prevention: focus on dietary treatments.
Harnessing the power of metabolism for seizure prevention: focus on dietary treatments.
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DOI：
10.1016/j.yebeh.2012.09.019
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Stafstrom CE
中科院分区：
文献类型：
--
作者：
Hartman AL;Stafstrom CE
尽管有近15种传统和新型抗惊厥药物可用，但至少三分之一的癫痫儿童和成人患者仍持续发生难治性癫痫发作，这表明迫切需要开发新的治疗方法。细胞代谢是细胞获取和利用能量的关键途径，对正常的神经元功能至关重要。此外，越来越多的证据表明能量代谢和细胞兴奋性之间存在直接联系。近一个世纪以来，高脂肪、低碳水化合物的生酮饮食一直被用作治疗药物难治性癫痫的方法。然而，针对细胞代谢和过度兴奋性的多种替代疗法几乎尚未开发。本综述中讨论的方法提供了广泛的治疗靶点，研究人员可以利用这些靶点寻找更安全、更有效的癫痫治疗方法。
The continued occurrence of refractory seizures in at least one-third of children and adults with epilepsy, despite the availability of almost 15 conventional and novel anticonvulsant drugs, speaks to a dire need to develop novel therapeutic approaches. Cellular metabolism, the critical pathways by which cells access and utilize energy, is critical for normal neuronal function. Furthermore, mounting evidence suggests direct links between energy metabolism and cellular excitability. The high-fat, low-carbohydrate ketogenic diet has been used as a treatment for drug-refractory epilepsy for almost a century. Yet, the multitude of alternative therapies to target aspects of cellular metabolism and hyperexcitability is almost untapped. Approaches discussed in this review offer a wide diversity of therapeutic targets that might be exploited by investigators in the search for safer and more effective epilepsy treatments.
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影响因子：
25
作者：
Chow, David K.;Groszer, Matthias;Pribadi, Mochtar;Machniki, Michal;Carmichael, S. Thomas;Liu, Xin;Trachtenberg, Joshua T.
通讯作者：
Trachtenberg, Joshua T.
影响因子：
1.7
作者：
Brockmann, Knut
通讯作者：
Brockmann, Knut
影响因子：
2.2
作者：
Barton, ME;Klein, BD;White, HS
通讯作者：
White, HS
影响因子：
2.2
作者：
Bough, KJ;Gudi, K;Eagles, DA
通讯作者：
Eagles, DA
影响因子：
5.6
作者：
APPLETON, DB;DEVIVO, DC
通讯作者：
DEVIVO, DC