Mental imagery-induced attention modulates pain perception and cortical excitability.
Mental imagery-induced attention modulates pain perception and cortical excitability.
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DOI：
10.1186/s12868-015-0146-6
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发表时间：
2015-03-15
期刊：
影响因子：
2.4
通讯作者：
Fregni F
中科院分区：
文献类型：
--
作者：
Volz MS;Suarez-Contreras V;Portilla AL;Fregni F
心理意象是一种改变大脑活动和行为结果的有效方法，例如认知和运动技能的表现。此外，注意力和分心可以调节与疼痛相关的神经元网络和对疼痛的感知。这项探索性研究使用经颅磁刺激(TMS)研究了心理意象引起的注意对压力、痛阈值和皮质可塑性的影响。这项盲法、随机、平行设计的试验包括30名健康的右撇子男性受试者。对疼痛和TMS评估采用单因素方差分析和t检验进行探索性统计分析。皮尔逊相关性被用来分析痛阈值变化和皮质兴奋性之间的联系。在疼痛结果分析中，组与时间之间对疼痛的交互作用不显著。在探索性分析中，我们只观察到目标左手的分组效应(以痛阈值为因变量，以时间和分组为自变量的方差分析)。虽然心理想象对疼痛只有组内效应，但进一步的分析表明，痛阈值的变化与皮质兴奋性(通过TMS的运动诱发电位)呈显著正相关。心理意象对健康受试者的疼痛调制作用不大。与慢性疼痛相比，其效果似乎有所不同，导致痛阈值略有下降。对大脑皮层兴奋性的评估证实，这些效应与痛觉相关的大脑皮层回路的调制有关。这些探索性的发现表明，神经元的可塑性受到疼痛的影响，心理表象对疼痛的影响取决于中枢敏化的状态。
Mental imagery is a powerful method of altering brain activity and behavioral outcomes, such as performance of cognition and motor skills. Further, attention and distraction can modulate pain-related neuronal networks and the perception of pain. This exploratory study examined the effects of mental imagery-induced attention on pressure pain threshold and cortical plasticity using transcranial magnetic stimulation (TMS). This blinded, randomized, and parallel-design trial comprised 30 healthy right-handed male subjects. Exploratory statistical analyses were performed using ANOVA and t-tests for pain and TMS assessments. Pearson’s correlation was used to analyze the association between changes in pain threshold and cortical excitability. In the analysis of pain outcomes, there was no significant interaction effect on pain between group versus time. In an exploratory analysis, we only observed a significant effect of group for the targeted left hand (ANOVA with pain threshold as the dependent variable and time and group as independent variables). Although there was only a within-group effect of mental imagery on pain, further analyses showed a significant positive correlation of changes in pain threshold and cortical excitability (motor-evoked potentials via TMS). Mental imagery has a minor effect on pain modulation in healthy subjects. Its effects appear to differ compared with chronic pain, leading to a small decrease in pain threshold. Assessments of cortical excitability confirmed that these effects are related to the modulation of pain-related cortical circuits. These exploratory findings suggest that neuronal plasticity is influenced by pain and that the mental imagery effects on pain depend on the state of central sensitization.
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