Fear erasure in mice requires synergy between antidepressant drugs and extinction training.
Fear erasure in mice requires synergy between antidepressant drugs and extinction training.
复制标题
DOI：
10.1126/science.1214592
复制
发表时间：
2011-12-23
期刊：
影响因子：
--
通讯作者：
Castrén E
中科院分区：
文献类型：
--
作者：
Karpova NN;Pickenhagen A;Lindholm J;Tiraboschi E;Kulesskaya N;Agústsdóttir A;Antila H;Popova D;Akamine Y;Bahi A;Sullivan R;Hen R;Drew LJ;Castrén E
抗抑郁药物和心理治疗相结合在治疗情绪障碍方面比单独治疗更有效，但这种相互作用的神经生物学基础尚不清楚。为了研究抗抑郁药如何影响情绪相关系统对行为体验的反应，我们在小鼠身上使用了恐惧调节和消退范例。将消退训练与慢性氟西汀相结合，但单独治疗，都不会导致成年动物条件性恐惧记忆的持久丧失。氟西汀治疗增加了突触可塑性，将恐惧记忆回路转变为更不成熟的状态，并通过局部脑源性神经营养因子发挥作用。氟西汀诱导的可塑性可以通过记忆电路的消退引导重塑来消除恐惧。因此，抗抑郁药的药理作用需要与心理康复相结合，以重组通过药物治疗而变得更具可塑性的网络。
Antidepressant drugs and psychotherapy combined are more effective in treating mood disorders than either treatment alone, but the neurobiological basis of this interaction is unknown. To investigate how antidepressants influence the response of mood-related systems to behavioral experience, we used a fear-conditioning and extinction paradigm in mice. Combining extinction training with chronic fluoxetine, but neither treatment alone, induced an enduring loss of conditioned fear memory in adult animals. Fluoxetine treatment increased synaptic plasticity, converted the fear memory circuitry to a more immature state, and acted through local brain-derived neurotrophic factor. Fluoxetine-induced plasticity may allow fear erasure by extinction-guided remodeling of the memory circuitry. Thus, the pharmacological effects of antidepressants need to be combined with psychological rehabilitation to reorganize networks rendered more plastic by the drug treatment.
登录
查看更多内容
影响因子：
2.7
作者：
Drephal, Christian;Schubert, Manja;Albrecht, Doris
通讯作者：
Albrecht, Doris
影响因子：
64.8
作者：
Sullivan, RM;Landers, M;Wilson, DA
通讯作者：
Wilson, DA
影响因子：
15.9
作者：
Mahan, Amy L.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
3.4
作者：
Deschaux, Olivier;Spennato, Guillaume;Garcia, Rene
通讯作者：
Garcia, Rene
影响因子：
56.9
作者：
Maya-Vetencourt, Jose Fernando;Sale, Alessandro;Maffei, Lamberto
通讯作者：
Maffei, Lamberto