Non-simian foamy viruses: molecular virology, tropism and prevalence and zoonotic/interspecies transmission.

Non-simian foamy viruses: molecular virology, tropism and prevalence and zoonotic/interspecies transmission.
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DOI:
10.3390/v5092169
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发表时间:
2013-09-13
期刊:
Viruses
影响因子:
--
通讯作者:
Materniak M
Materniak M
中科院分区:
其他
文献类型:
--
作者:
Kehl T;Tan J;Materniak M

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在逆转录病毒领域,我们对泡沫病毒(FV)的了解仍然有限。它们独特的复制策略和病毒持续存在的机制需要进一步研究,以了解病毒-宿主相互作用,特别是鉴于最近的研究结果表明它们的古老起源和与非人类宿主的长期共同进化。毫无疑问,研究最多的成员是灵长类/原型泡沫病毒(PFV),最初从人类分离出来(称为人类泡沫病毒,HFV),但后来被确定为黑猩猩起源;系统发育分析清楚地将其置于其他旧世界灵长类动物中。此外,对非猿类动物FV的研究有助于更深入地了解FV-宿主相互作用和其他动物模型的开发。该综述旨在突出特别感兴趣的领域的结构,生物学,病毒-宿主相互作用和灵长类动物以及非灵长类动物泡沫病毒的种间传播潜力,以获得新的见解FV生物学。
Within the field of retrovirus, our knowledge of foamy viruses (FV) is still limited. Their unique replication strategy and mechanism of viral persistency needs further research to gain understanding of the virus-host interactions, especially in the light of the recent findings suggesting their ancient origin and long co-evolution with their nonhuman hosts. Unquestionably, the most studied member is the primate/prototype foamy virus (PFV) which was originally isolated from a human (designated as human foamy virus, HFV), but later identified as chimpanzee origin; phylogenetic analysis clearly places it among other Old World primates. Additionally, the study of non-simian animal FVs can contribute to a deeper understanding of FV-host interactions and development of other animal models. The review aims at highlighting areas of special interest regarding the structure, biology, virus-host interactions and interspecies transmission potential of primate as well as non-primate foamy viruses for gaining new insights into FV biology.
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