FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy.
FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy.
复制标题
DOI：
10.3390/ijms21186492
复制
发表时间：
2020-09-05
影响因子：
5.6
通讯作者：
Parsons JL
中科院分区：
文献类型：
--
作者：
Hughes JR;Parsons JL
FLASH放射治疗是提供超高剂量率辐射，比目前在传统临床放射治疗中使用的高几个数量级，并有可能彻底改变癌症治疗的未来。FLASH放射疗法诱导称为FLASH效应的现象，由此超高剂量率辐射降低通常与常规放射疗法相关的正常组织毒性，同时仍保持局部肿瘤控制。闪光效应的潜在机制尚未完全阐明，但氧张力和活性氧产生的重要作用是目前最有效的假设。近年来，在体外和体内的许多研究中已经证实了FLASH效应，甚至第一个T细胞皮肤淋巴瘤患者使用FLASH放疗进行治疗。然而，大多数对FLASH放射治疗的研究都使用了组织穿透力低的电子束，这对转化为临床实践存在限制。一种有前景的替代FLASH输送方法是通过质子束治疗，因为剂量可以沉积在组织内更深处。然而，目前对FLASH质子的研究很少。本文将总结FLASH放射治疗的研究进行了日期和目前的理论解释FLASH效应，重点放在未来的潜力FLASH质子束治疗。
FLASH radiotherapy is the delivery of ultra-high dose rate radiation several orders of magnitude higher than what is currently used in conventional clinical radiotherapy, and has the potential to revolutionize the future of cancer treatment. FLASH radiotherapy induces a phenomenon known as the FLASH effect, whereby the ultra-high dose rate radiation reduces the normal tissue toxicities commonly associated with conventional radiotherapy, while still maintaining local tumor control. The underlying mechanism(s) responsible for the FLASH effect are yet to be fully elucidated, but a prominent role for oxygen tension and reactive oxygen species production is the most current valid hypothesis. The FLASH effect has been confirmed in many studies in recent years, both in vitro and in vivo, with even the first patient with T-cell cutaneous lymphoma being treated using FLASH radiotherapy. However, most of the studies into FLASH radiotherapy have used electron beams that have low tissue penetration, which presents a limitation for translation into clinical practice. A promising alternate FLASH delivery method is via proton beam therapy, as the dose can be deposited deeper within the tissue. However, studies into FLASH protons are currently sparse. This review will summarize FLASH radiotherapy research conducted to date and the current theories explaining the FLASH effect, with an emphasis on the future potential for FLASH proton beam therapy.
登录
查看更多内容
影响因子：
2
作者：
Antonovic L;Lindblom E;Dasu A;Bassler N;Furusawa Y;Toma-Dasu I
通讯作者：
Toma-Dasu I
影响因子：
3.4
作者：
CYGLER, J;KLASSEN, NV;RAAPHORST, GP
通讯作者：
RAAPHORST, GP
影响因子：
1.4
作者：
Grimes DR;Partridge M
通讯作者：
Partridge M
DOI：
10.1016/j.ijrobp.2017.11.012
发表时间：
2018-03-01
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Carter RJ;Nickson CM;Thompson JM;Kacperek A;Hill MA;Parsons JL
通讯作者：
Parsons JL
影响因子：
3.4
作者：
EPP, ER;WEISS, H;SANTOMASSO, A
通讯作者：
SANTOMASSO, A