The diverse roles of macrophages in metabolic inflammation and its resolution.
The diverse roles of macrophages in metabolic inflammation and its resolution.
复制标题
DOI：
10.3389/fcell.2023.1147434
复制
发表时间：
2023
影响因子：
5.5
通讯作者：
Weinstock, Ada
中科院分区：
文献类型：
--
作者：
Ray, Aleepta Guha;Odum, Oluwatomilayo Patience;Wiseman, Destini;Weinstock, Ada
关键词：
巨噬细胞是功能最多样化的免疫细胞之一，对于维持组织完整性和代谢健康不可或缺。巨噬细胞执行多种功能，从促进炎症、消解炎症到恢复和维持组织稳态。代谢疾病包括越来越多的疾病，这些疾病是由遗传和环境因素共同导致的，导致代谢失调和随后的炎症。在这篇综述中，我们总结了巨噬细胞对四种代谢状况的贡献——胰岛素抵抗和脂肪组织炎症、动脉粥样硬化、非酒精性脂肪肝和神经变性。巨噬细胞的作用很复杂，但它们作为解决这些日益严重的健康问题的潜在疗法具有广阔的前景。
Macrophages are one of the most functionally diverse immune cells, indispensable to maintain tissue integrity and metabolic health. Macrophages perform a myriad of functions ranging from promoting inflammation, through inflammation resolution to restoring and maintaining tissue homeostasis. Metabolic diseases encompass a growing list of diseases which develop from a mix of genetics and environmental cues leading to metabolic dysregulation and subsequent inflammation. In this review, we summarize the contributions of macrophages to four metabolic conditions–insulin resistance and adipose tissue inflammation, atherosclerosis, non-alcoholic fatty liver disease and neurodegeneration. The role of macrophages is complex, yet they hold great promise as potential therapies to address these growing health concerns.
登录
查看更多内容
影响因子：
29
作者：
Berry R;Jeffery E;Rodeheffer MS
通讯作者：
Rodeheffer MS
影响因子：
29
作者：
Babaev, Vladimir R.;Chew, Joshua D.;Ding, Lei;Davis, Sarah;Breyer, Matthew D.;Breyer, Richard M.;Oates, John A.;Fazio, Sergio;Linton, MacRae F.
通讯作者：
Linton, MacRae F.
影响因子：
20.1
作者：
Afonso MS;Sharma M;Schlegel M;van Solingen C;Koelwyn GJ;Shanley LC;Beckett L;Peled D;Rahman K;Giannarelli C;Li H;Brown EJ;Khodadadi-Jamayran A;Fisher EA;Moore KJ
通讯作者：
Moore KJ
影响因子：
12.7
作者：
Baufeld C;Osterloh A;Prokop S;Miller KR;Heppner FL
通讯作者：
Heppner FL
DOI：
10.4049/jimmunol.1602175
发表时间：
2017-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Aziz MH;Cui K;Das M;Brown KE;Ardell CL;Febbraio M;Pluskota E;Han J;Wu H;Ballantyne CM;Smith JD;Cathcart MK;Yakubenko VP
通讯作者：
Yakubenko VP