Effects of curcumin on retinal oxidative stress and inflammation in diabetes.
Effects of curcumin on retinal oxidative stress and inflammation in diabetes.
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DOI：
10.1186/1743-7075-4-8
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发表时间：
2007-04-16
影响因子：
4.5
通讯作者：
Kanwar M
中科院分区：
文献类型：
--
作者：
Kowluru RA;Kanwar M
氧化应激和炎症与糖尿病视网膜病变的发病机制有关。本研究的目的是研究姜黄素，一种具有抗氧化和抗炎特性的多酚，对糖尿病诱导的大鼠视网膜氧化应激和炎症的影响。一组链脲佐菌素诱导的糖尿病大鼠接受添加0.05%姜黄素（w/w）的粉末状饮食，另一组接受不含姜黄素的饮食。在诱导糖尿病后不久开始饮食，并在诱导糖尿病后6周处死大鼠。视网膜用于量化氧化应激和促炎标志物。糖尿病大鼠视网膜的抗氧化能力和细胞内抗氧化剂水平、GSH（还原型谷胱甘肽）水平降低约30- 35%，氧化修饰的DNA（8-OHdG）和硝基酪氨酸增加60-70%。白细胞介素1β（IL-1β）和血管内皮生长因子（VEGF）水平分别升高30%和110%，核转录因子（NF-κ B）活化2倍。姜黄素管理防止糖尿病诱导的抗氧化能力下降，增加8-OHdG和硝基酪氨酸，但它只有部分有益的影响视网膜GSH。姜黄素还抑制糖尿病诱导的IL-1β、VEGF和NF-kB水平的升高。姜黄素的作用没有改善高血糖的严重程度。因此，姜黄素对代谢异常的有益作用被认为在糖尿病视网膜病变的发展中是重要的，这表明姜黄素在抑制糖尿病患者视网膜病变的发展中可能具有潜在的益处。
Oxidative stress and inflammation are implicated in the pathogenesis of retinopathy in diabetes. The aim of this study is to examine the effect of curcumin, a polyphenol with antioxidant and anti-inflammatory properties, on diabetes-induced oxidative stress and inflammation in the retina of rats. A group of streptozotocin-induced diabetic rats received powdered diet supplemented with 0.05% curcumin (w/w), and another group received diet without curcumin. The diets were initiated soon after induction of diabetes, and the rats were sacrificed 6 weeks after induction of diabetes. The retina was used to quantify oxidative stress and pro-inflammatory markers. Antioxidant capacity and the levels of intracellular antioxidant, GSH (reduced form of glutathione) levels were decreased by about 30–35%, and oxidatively modified DNA (8-OHdG) and nitrotyrosine were increased by 60–70% in the retina of diabetic rats. The levels of interleukin-1β (IL-1β) and vascular endothelial growth factor (VEGF) were elevated by 30% and 110% respectively, and the nuclear transcription factor (NF-kB) was activated by 2 fold. Curcumin administration prevented diabetes-induced decrease in the antioxidant capacity, and increase in 8-OHdG and nitrotyrosine; however, it had only partial beneficial effect on retinal GSH. Curcumin also inhibited diabetes-induced elevation in the levels of IL-1β, VEGF and NF-kB. The effects of curcumin were achieved without amelioration of the severity of hyperglycemia. Thus, the beneficial effects of curcumin on the metabolic abnormalities postulated to be important in the development of diabetic retinopathy suggest that curcumin could have potential benefits in inhibiting the development of retinopathy in diabetic patients.
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影响因子：
4.5
作者：
Farhangkhoee, Hana;Khan, Zia A;Chen, Shali;Chakrabarti, Subrata
通讯作者：
Chakrabarti, Subrata
影响因子：
5.6
作者：
Hsuuw, YD;Chang, CK;Yu, JS
通讯作者：
Yu, JS
影响因子：
3.4
作者：
Koracevic, D;Koracevic, G;Cosic, V
通讯作者：
Cosic, V
影响因子：
7.7
作者：
Baynes, JW;Thorpe, SR
通讯作者：
Thorpe, SR
影响因子：
7.7
作者：
Kowluru, RA;Odenbach, S
通讯作者：
Odenbach, S