Autophagic control of listeria through intracellular innate immune recognition in drosophila.
Autophagic control of listeria through intracellular innate immune recognition in drosophila.
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自噬是一种进化上保守的细胞质成分分解代谢的稳态过程，在哺乳动物先天免疫应答过程中参与了细胞内病原体的清除。然而，细胞质感染诱导的自噬的机制，以及自噬在宿主抵抗细胞内病原体的存活中的作用尚不清楚。在这里，我们报告说，在果蝇中，识别二氨基庚二酸型肽聚糖的模式识别受体PGRP-LE的诱导自噬是至关重要的，自噬防止单核细胞增生李斯特菌的细胞内生长，并促进宿主对这种感染的生存。自噬诱导独立于Toll和IMD先天信号传导途径发生。这些发现明确了从细胞内模式识别受体诱导自噬到宿主防御的通路。
Autophagy, an evolutionally conserved homeostatic process for catabolizing cytoplasmic components, has been implicated in the elimination of intracellular pathogens during mammalian innate immune responses. However, the mechanisms underlying cytoplasmic infection-induced autophagy, and the role of autophagy in host survival against intracellular pathogens are unknown. Here we report that in drosophila, recognition of diaminopimelic acid-type peptidoglycans by the pattern recognition receptor PGRP-LE is crucial for the induction of autophagy, and that autophagy prevents the intracellular growth of Listeria monocytogenes and promotes host survival against this infection. Autophagy induction occurs independently of the Toll and IMD innate signaling pathways. These findings define a clear pathway leading from the intracellular pattern recognition receptors to the induction of autophagy to host defense.
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