Circadian control of global gene expression patterns.
Circadian control of global gene expression patterns.
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DOI：
10.1146/annurev-genet-102209-163432
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发表时间：
2010
影响因子：
11.1
通讯作者：
Kay SA
中科院分区：
文献类型：
--
作者：
Doherty CJ;Kay SA
从古生菌到人类，几乎在每一种生物中都观察到了内部的计时机制。这种生物钟在健身和生存方面提供了竞争优势。研究人员通过结合酶学，分子生物学，遗传学和建模方法，揭示了这种内部时钟的分子组成。然而，理解时钟和输出响应之间的机械联系一直难以捉摸。在拟南芥、黑腹果蝇和小家鼠这三种模式生物中，全基因组表达阵列使研究人员能够研究维持时间保持机制如何与适应性优势联系起来。在这里，我们回顾了转录组学对我们理解生物钟的影响，以及这种分子钟如何与系统水平的昼夜节律反应联系起来。我们探索了高通量RNA检测所带来的发现，用于研究这些大型转录数据集的网络方法，以及潜在的未来方向。
An internal time-keeping mechanism has been observed in almost every organism studied from archaea to humans. This circadian clock provides a competitive advantage in fitness and survival. Researchers have uncovered the molecular composition of this internal clock by combining enzymology, molecular biology, genetics, and modeling approaches. However, understanding the mechanistic link between the clock and output responses has been elusive. In three model organisms, Arabidopsis thaliana, Drosophila melanogaster, and Mus musculus, whole-genome expression arrays have enabled researchers to investigate how maintaining a time-keeping mechanism connects to an adaptive advantage. Here, we review the impacts transcriptomics have had on our understanding of the clock and how this molecular clock connects with system-level circadian responses. We explore the discoveries made possible by high-throughput RNA assays, the network approaches used to investigate these large transcript datasets, and potential future directions.
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影响因子：
4.5
作者：
Demogines, Ann;Smith, Erin;Kruglyak, Leonid;Alani, Eric
通讯作者：
Alani, Eric
DOI：
10.1196/annals.1417.006
发表时间：
2008-01-01
期刊：
MOLECULAR AND BIOPHYSICAL MECHANISMS OF AROUSAL, ALERTNESS, AND ATTENTION
影响因子：
--
作者：
Boothroyd, Catharine E.;Young, Michael W.
通讯作者：
Young, Michael W.
影响因子：
56.9
作者：
Dodd, Antony N.;Gardner, Michael J.;Webb, Alex A. R.
通讯作者：
Webb, Alex A. R.
影响因子：
12.3
作者：
Covington, Michael F.;Maloof, Julin N.;Straume, Marty;Kay, Steve A.;Harmer, Stacey L.
通讯作者：
Harmer, Stacey L.
影响因子：
5.8
作者：
de Lichtenberg, U;Jensen, LJ;Brunak, S
通讯作者：
Brunak, S