Harmful Effects and Potential Benefits of Anti-Tumor Necrosis Factor (TNF)-α on the Liver.
Harmful Effects and Potential Benefits of Anti-Tumor Necrosis Factor (TNF)-α on the Liver.
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DOI：
10.3390/ijms19082199
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发表时间：
2018-07-27
影响因子：
5.6
通讯作者：
Papa A
中科院分区：
文献类型：
--
作者：
Lopetuso LR;Mocci G;Marzo M;D'Aversa F;Rapaccini GL;Guidi L;Armuzzi A;Gasbarrini A;Papa A
抗肿瘤坏死因子（TNF）-α药物是治疗慢性炎症性疾病的有效方法。然而，据报道，它们对肝功能可能产生不良影响。另一方面，越来越多的证据表明它们对某些肝脏疾病具有治疗作用。许多数据表明，即使建议在明确的亚组中进行严格的随访和预防，抗-TNF-α对于慢性乙型和丙型肝炎患者以及肝移植患者也是安全的。另一方面，抗TNF-α引起的肝损伤并非罕见事件。然而，抗 TNF-α 停药后，这种情况通常是可逆的。抗 TNF-α 药物已在严重酒精性肝炎和非酒精性脂肪肝的晚期阶段进行了测试。关于抗 TNF-α 对自身免疫性肝炎和原发性胆汁性胆管炎患者的疗效的数据也有限。在这篇综述中，我们探讨了患有或不患有肝脏疾病的接受抗 TNF-α 药物治疗的患者的肝脏安全问题。此外，还讨论了它们在治疗特定肝脏疾病方面的潜在益处的现有证据。
Anti-tumor necrosis factor (TNF)-α agents represent an effective treatment for chronic inflammatory diseases. However, some concerns about their potentially undesirable effects on liver function have been reported. On the other hand, evidence of their therapeutic effects on certain liver diseases is accumulating. Many data showed the safety of anti-TNF-α in patients with chronic hepatitis B and C and in liver transplanted patients even if a strict follow-up and prophylaxis are recommended in well-defined subgroups. On the other side, anti-TNF-α-induced liver injury is not a rare event. However, it is often reversible after anti-TNF-α withdrawal. Anti-TNF-α agents have been tested in advanced stages of severe alcoholic hepatitis and non-alcoholic fatty liver disease. Limited data on the efficacy of anti-TNF-α in patients with autoimmune hepatitis and primary biliary cholangitis are also available. In this review, we explored the hepatic safety concerns in patients receiving anti-TNF-α agents with and without pre-existent hepatic diseases. In addition, the available evidence on their potential benefits in the treatment of specific hepatic diseases is discussed.
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影响因子：
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作者：
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DOI：
10.1097/00042737-200504000-00012
发表时间：
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