Endothelium-Dependent Hyperpolarization (EDH) in Hypertension: The Role of Endothelial Ion Channels.
Endothelium-Dependent Hyperpolarization (EDH) in Hypertension: The Role of Endothelial Ion Channels.
复制标题
DOI：
10.3390/ijms19010315
复制
发表时间：
2018-01-21
影响因子：
5.6
通讯作者：
Kitazono T
中科院分区：
文献类型：
--
作者：
Goto K;Ohtsubo T;Kitazono T
在用激动剂和剪切应力刺激时，不同血管的血管内皮选择性地释放几种血管舒张因子，如一氧化氮和前列环素。此外，许多血管的血管内皮细胞通过产生内皮依赖性超极化（EDH）来调节血管平滑肌细胞的收缩性。有一个普遍的共识，即小电导和中等电导的钙激活的K+通道（SKCa和IKCa）的开放是产生EDH的初始机制步骤。在动物模型和人类中，EDH和EDH介导的舒张功能在高血压期间受损，抗高血压治疗可以恢复这种损伤。然而，降低EDH的潜在机制以及通过降低血压来改善EDH的机制知之甚少。新出现的证据表明，内皮离子通道如SKCa通道、内向整流K+通道、Ca2+激活的Cl−通道和瞬时受体电位香草酸4型通道的改变有助于高血压期间EDH受损。本文综述了近年来内皮细胞离子通道在高血压病中的病理生理作用，重点阐述了其与EDH的关系。
Upon stimulation with agonists and shear stress, the vascular endothelium of different vessels selectively releases several vasodilator factors such as nitric oxide and prostacyclin. In addition, vascular endothelial cells of many vessels regulate the contractility of the vascular smooth muscle cells through the generation of endothelium-dependent hyperpolarization (EDH). There is a general consensus that the opening of small- and intermediate-conductance Ca2+-activated K+ channels (SKCa and IKCa) is the initial mechanistic step for the generation of EDH. In animal models and humans, EDH and EDH-mediated relaxations are impaired during hypertension, and anti-hypertensive treatments restore such impairments. However, the underlying mechanisms of reduced EDH and its improvement by lowering blood pressure are poorly understood. Emerging evidence suggests that alterations of endothelial ion channels such as SKCa channels, inward rectifier K+ channels, Ca2+-activated Cl− channels, and transient receptor potential vanilloid type 4 channels contribute to the impaired EDH during hypertension. In this review, we attempt to summarize the accumulating evidence regarding the pathophysiological role of endothelial ion channels, focusing on their relationship with EDH during hypertension.
登录
查看更多内容
影响因子：
20.1
作者：
Campbell, WB;Gebremedhin, D;Harder, DR
通讯作者：
Harder, DR
影响因子：
8.3
作者：
Dohi, Y;Kojima, M;Sato, K
通讯作者：
Sato, K
影响因子：
4
作者：
Cheang, Wai San;Wong, Wing Tak;Huang, Yu
通讯作者：
Huang, Yu
影响因子：
56.9
作者：
Caputo, Antonella;Caci, Emanuela;Galietta, Luis J. V.
通讯作者：
Galietta, Luis J. V.
影响因子：
6
作者：
Bund, SJ
通讯作者：
Bund, SJ