Emerging Roles for Phase Separation in Plants.
Emerging Roles for Phase Separation in Plants.
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DOI：
10.1016/j.devcel.2020.09.010
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发表时间：
2020-10-12
影响因子：
11.8
通讯作者：
Strader LC
中科院分区：
文献类型：
--
作者：
Emenecker RJ;Holehouse AS;Strader LC
植物细胞内环境是一个动态的，复杂的景观组成的许多细胞内室。细胞通过形成生物分子缩合物-蛋白质和/或核酸的非化学计量组装体来组织一些细胞组分。在许多情况下，相分离似乎是生物分子凝聚物形成的基础或促成生物分子凝聚物的形成。动物细胞内许多典型的无膜区室以至少与相分离一致的方式形成，包括核仁、应激颗粒、卡哈尔体和许多受发育和环境刺激调节的其他体。在这篇综述中，我们研究了植物中相分离的新作用。此外，借鉴在其他生物体中进行的研究，我们确定了植物中也可能通过相分离产生的细胞现象。我们提出，植物利用相分离的程度比以前认识到的要大得多，暗示相分离是细胞组织的一种进化上古老的机制。细胞可以通过形成无膜区室来组织细胞组分。在动物和真菌系统中，许多无膜区室通过细胞内相分离形成。在这里，Emenecker等人研究了植物中相分离的作用。
The plant cell internal environment is a dynamic, intricate landscape composed of many intracellular compartments. Cells organize some cellular components through formation of biomolecular condensates - non-stoichiometric assemblies of protein and/or nucleic acids. In many cases, phase separation appears to either underly or contribute to the formation of biomolecular condensates. Many canonical membraneless compartments within animal cells form in a manner that is at least consistent with phase separation, including nucleoli, stress granules, Cajal bodies, and numerous additional bodies regulated by developmental and environmental stimuli. In this review, we examine the emerging roles for phase separation in plants. Further, drawing on studies carried out in other organisms, we identify cellular phenomenon in plants that may also arise via phase separation. We propose that plants make use of phase separation to a much greater extent than has been previously appreciated, implicating phase separation as an evolutionarily ancient mechanism for cellular organization. Cells can organize cellular components through the formation of membraneless compartments. In animal and fungal systems, many membraneless compartments form via intracellular phase separation. Here, Emenecker et al. examine roles for phase separation in plants.
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