Polycythemia Vera Presenting as Hemorrhagic Stroke.
Polycythemia Vera Presenting as Hemorrhagic Stroke.
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DOI：
10.1055/s-0041-1729478
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发表时间：
2021-07
影响因子：
1.4
通讯作者：
Jacob JP
中科院分区：
文献类型：
--
作者：
Balagopal K;Mathew A;Koshy AG;Jacob JP
真性红细胞增多症患者发生血管闭塞事件的风险很高，包括脑缺血和出血。脑缺血事件是由于血液粘度增加和中枢神经系统动脉血管内的血小板激活所致。我们报告一例65岁女性患者，她在急诊科出现癫痫发作，随后出现左侧无力。血液学检查显示为高粘性状态，磁共振成像(MRI)与双侧出血性脑梗塞相一致。遗传学研究显示真性红细胞增多症突变阳性。经静脉采血和抗血小板药物治疗后，症状有所改善。通过这个病例，我们旨在强调真性红细胞增多症是出血性卒中的一个原因，以及血细胞计数在常规评估中的重要性。
Patients with polycythemia vera are at high risk for vaso-occlusive events including cerebral ischemia and hemorrhage. Cerebral ischemic events are due to increased blood viscosity and platelet activation within the central nervous system arterial vessels. We present a case of a 65-year-old woman who presented to the emergency department with seizures followed by left-sided weakness. Hematologic investigations revealed a hyperviscous state, and magnetic resonance imaging (MRI) was consistent with bilateral hemorrhagic infarction. Genetic studies were positive for polycythemia vera mutation. Symptoms improved with phlebotomy and antiplatelet agents. Through this case, we aim to highlight polycythemia vera as a cause of hemorrhagic stroke and the importance of blood counts in the routine evaluation of the same.
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影响因子：
50.3
作者：
Levine, RL;Wadleigh, M;Gilliland, DG
通讯作者：
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影响因子：
158.5
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