Age trends for hip geometry in Chinese men and women and the association with femoral neck fracture
Age trends for hip geometry in Chinese men and women and the association with femoral neck fracture
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中国男性和女性髋关节几何形状的年龄趋势及其与股骨颈骨折的关系
DOI：
10.1007/s00198-010-1479-8
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发表时间：
2010-10
影响因子：
4
通讯作者：
Zhang, Z. L.
中科院分区：
文献类型：
--
作者：
Hu, Y. Q.;Zhang, H.;Zhang, Z. L.
应用双能X线骨密度仪（DXA）测量了18，502名健康中国人（14，435名女性和4，067名男性）、254名股骨颈骨折患者和254名年龄和性别匹配的对照者的髋部骨密度（BMD）和髋部几何参数。研究结果表明，中国男性和女性股骨颈皮质层厚度随年龄增长而变薄，强度指数（SI）随年龄增长而下降。SI可能是一个危险因素髋部骨折在中国women.IntroductionThe本研究的目的是评估年龄相关的趋势，在健康的中国男性和女性的髋关节几何形状，并检查是否在髋关节几何参数的变化是一个危险因素髋部fractions.MethodsWe招募了14,435名妇女和4,067名男子作为研究人群。有254名受试者（216名女性，38名男性）患有股骨颈骨折; 254名年龄和性别匹配的健康人作为对照。应用髋关节DXA图像计算髋关节BMD和髋关节几何参数，包括髋轴长（HAL）、横截面惯性矩（CSMI）、横截面面积（CSA）、颈干角（NSA）和股骨SI。然而，在调整身高和体重后，HAL随年龄增加，CSMI和年龄之间没有很强的相关性。在两种性别中，骨折病例的髋部BMD和CSA均显著低于对照组。调整髋部BMD后，女性中仅SI较小（优势比[OR] 1.53; 95%置信区间[CI]，1.04-2.26）预测髋部骨折，但在男性中，没有一个几何参数与髋部骨折风险相关。结论这项研究表明，中国男性股骨颈皮质壳变薄，抗弯曲和SI随年龄增长而恶化，妇女SI可能是中国女性髋部骨折的一个独立危险因素。
SummaryHip dual-energy X-ray absorptiometry (DXA) images were used to calculate hip bone mineral density (BMD) and hip geometry parameters of 18,502 healthy Chinese people (14,435 women and 4,067 men), 254 subjects sustained a femoral neck fracture and 254 age- and sex-matched controls. Our study showed that thinning of the cortical shell and deterioration of the strength index (SI) in femoral neck with aging in both Chinese men and women. SI may be a risk factor for hip fracture in Chinese women.IntroductionThe purpose of this study was to evaluate age-related trends in the hip geometry of healthy Chinese men and women and to examine whether changes in hip geometric parameters is one of the risk factors of hip fracture.MethodsWe recruited 14,435 women and 4,067 men as the study population. There were 254 subjects (216 women, 38 men) who had sustained a femoral neck fracture; 254 age- and sex-matched healthy persons served as controls. Hip DXA images were used to calculate hip BMD and hip geometry parameters, including the hip axis length (HAL), cross-sectional moment of inertia (CSMI), cross-sectional area (CSA), neck–shaft angle (NSA) and femoral SI.ResultsHip BMD, CSMI, CSA and SI showed significantly negative correlations with age. However, after adjustment for height and weight, HAL increased with age, and there was no strong correlation between CSMI and age in either sex. In both genders, hip BMD and CSA were significant lower in fracture cases compared with controls. After adjustment for hip BMD, in women only smaller SI (odds ratio [OR] 1.53; 95% confidence interval [CI], 1.04–2.26) was predictive of hip fracture but in men, none of the geometry parameters was associated with hip fracture risk.ConclusionsThis study demonstrated thinning of the cortical shell and deterioration of the resistance to bending and SI with aging in femoral neck in Chinese men and women. SI may be a risk factor for hip fracture that is independent of BMD measurement in Chinese women.
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作者：
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