Hippo Signaling Pathway in Gliomas.
Hippo Signaling Pathway in Gliomas.
复制标题
神经胶质瘤中的海马信号通路
DOI：
10.3390/cells10010184
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发表时间：
2021-01-18
期刊：
影响因子：
6
通讯作者：
Guichet PO
中科院分区：
文献类型：
--
作者：
Masliantsev K;Karayan-Tapon L;Guichet PO
Hippo信号通路是参与组织发育和再生的高度保守的通路，其通过调节细胞增殖和凋亡来控制器官大小。核心Hippo通路由一组激酶MST 1/2（哺乳动物STE 20样蛋白激酶1/2）和LATS 1/2（大肿瘤抑制因子1/2）组成，其抑制雅普/TAZ（Yes-Associated Protein 1/Transcriptional co-activator with PDZ-binding motif）的核转位及其与转录因子TEAD（TEA domain）家族的下游关联。该途径最近被证明参与几种癌症如肺癌、乳腺癌或结直肠癌的肿瘤发生和转移，但在脑肿瘤中的研究仍然很少。脑胶质瘤是最常见和最致命的原发性脑肿瘤，约占中枢神经系统恶性肿瘤的80%。尽管有密集的临床方案，由于系统性复发和治疗失败，患者的预后仍然非常差。越来越多的证据表明Hippo信号传导在癌症生物学中的作用，以及缺乏对恶性胶质瘤的有效治疗，支持这种途径可能代表一种潜在的靶点，为替代疗法铺平道路。基于Hippo通路的最新进展，本文综述的主要目标是通过最先进的合成方法来强调该通路在胶质瘤中的作用。
The Hippo signaling pathway is a highly conserved pathway involved in tissue development and regeneration that controls organ size through the regulation of cell proliferation and apoptosis. The core Hippo pathway is composed of a block of kinases, MST1/2 (Mammalian STE20-like protein kinase 1/2) and LATS1/2 (Large tumor suppressor 1/2), which inhibits nuclear translocation of YAP/TAZ (Yes-Associated Protein 1/Transcriptional co-activator with PDZ-binding motif) and its downstream association with the TEAD (TEA domain) family of transcription factors. This pathway was recently shown to be involved in tumorigenesis and metastasis in several cancers such as lung, breast, or colorectal cancers but is still poorly investigated in brain tumors. Gliomas are the most common and the most lethal primary brain tumors representing about 80% of malignant central nervous system neoplasms. Despite intensive clinical protocol, the prognosis for patients remains very poor due to systematic relapse and treatment failure. Growing evidence demonstrating the role of Hippo signaling in cancer biology and the lack of efficient treatments for malignant gliomas support the idea that this pathway could represent a potential target paving the way for alternative therapeutics. Based on recent advances in the Hippo pathway deciphering, the main goal of this review is to highlight the role of this pathway in gliomas by a state-of-the-art synthesis.
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DOI：
10.1056/nejmoa1407279
发表时间：
2015-06-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Eckel-Passow JE;Lachance DH;Molinaro AM;Walsh KM;Decker PA;Sicotte H;Pekmezci M;Rice T;Kosel ML;Smirnov IV;Sarkar G;Caron AA;Kollmeyer TM;Praska CE;Chada AR;Halder C;Hansen HM;McCoy LS;Bracci PM;Marshall R;Zheng S;Reis GF;Pico AR;O'Neill BP;Buckner JC;Giannini C;Huse JT;Perry A;Tihan T;Berger MS;Chang SM;Prados MD;Wiemels J;Wiencke JK;Wrensch MR;Jenkins RB
通讯作者：
Jenkins RB
Mst1 通过 AKT/mTOR 信号通路调节胶质瘤细胞增殖
影响因子：
3.9
作者：
Chao, Yuewen;Wang, Yan;Zhou, Xiuping
通讯作者：
Zhou, Xiuping
影响因子：
64.5
作者：
Dong, Jixin;Feldmann, Georg;Pan, Duojia
通讯作者：
Pan, Duojia
影响因子：
11.2
作者：
Galli, R;Binda, E;Vescovi, A
通讯作者：
Vescovi, A
影响因子：
7.5
作者：
Guo, Zhifei;Li, Guangyuan;Zhao, Bing
通讯作者：
Zhao, Bing