Associations of gestational weight gain with maternal body mass index, waist circumference, and blood pressure measured 16 y after pregnancy: the Avon Longitudinal Study of Parents and Children (ALSPAC).
Associations of gestational weight gain with maternal body mass index, waist circumference, and blood pressure measured 16 y after pregnancy: the Avon Longitudinal Study of Parents and Children (ALSPAC).
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DOI：
10.3945/ajcn.110.008326
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Lawlor DA
中科院分区：
文献类型：
--
作者：
Fraser A;Tilling K;Macdonald-Wallis C;Hughes R;Sattar N;Nelson SM;Lawlor DA
背景：妊娠期体重增加（GWG）与长期母体健康的关系知之甚少。目的：我们的目的是研究孕前体重和GWG与孕妇体重指数（BMI; kg/m2），腰围（WC），收缩压（SBP）和舒张压（DBP）16年后怀孕。设计图：这是一项在雅芳父母和孩子纵向研究（ALSPAC）的2356名母亲中进行的前瞻性研究-一项基于人群的妊娠队列研究。结果如下：根据医学研究所的建议，GWG低的女性的平均BMI（-1.56; 95% CI：-2.12，-1.00）和WC（-3.37 cm;-4.91，-1.83 cm）低于体重增加的女性。高GWG女性的平均BMI（2.90; 2.27，3.52）、WC（5.84 cm; 4.15，7.54 cm）、SBP（2.87 mm Hg; 1.22，4.52 mm Hg）和DBP（1.00 mm Hg;-0.02，2.01 mm Hg）更高。分析调整了年龄，后代性别，社会阶层，产次，吸烟，体力活动和饮食在怀孕期间，分娩方式和母乳喂养。高GWG的女性超重和中心性肥胖的几率增加了3倍。根据随机效应多水平模型的估计，孕前体重与所有结局呈正相关。妊娠各阶段的GWG与以后的BMI、WC、超重或肥胖的几率增加以及中心性肥胖呈正相关。妊娠中期（19-28周）的GWG与后期更高的SBP、DBP和中心性肥胖相关，但仅限于孕前BMI正常的妇女。结论：结果支持旨在优化孕前体重的举措。关于最佳GWG的建议需要平衡母亲和后代中不同结果的对比关联。
Background: Little is known about associations of gestational weight gain (GWG) with long-term maternal health. Objective: We aimed to examine associations of prepregnancy weight and GWG with maternal body mass index (BMI; in kg/m2), waist circumference (WC), systolic blood pressure (SBP), and diastolic blood pressure (DBP) 16 y after pregnancy. Design: This is a prospective study in 2356 mothers from the Avon Longitudinal Study of Parents and Children (ALSPAC)—a population-based pregnancy cohort. Results: Women with low GWG by Institute of Medicine recommendations had a lower mean BMI (−1.56; 95% CI: −2.12, −1.00) and WC (−3.37 cm; −4.91, −1.83 cm) than did women who gained weight as recommended. Women with a high GWG had a greater mean BMI (2.90; 2.27, 3.52), WC (5.84 cm; 4.15, 7.54 cm), SBP (2.87 mm Hg; 1.22, 4.52 mm Hg), and DBP (1.00 mm Hg; −0.02, 2.01 mm Hg). Analyses were adjusted for age, offspring sex, social class, parity, smoking, physical activity and diet in pregnancy, mode of delivery, and breastfeeding. Women with a high GWG had 3-fold increased odds of overweight and central adiposity. On the basis of estimates from random-effects multilevel models, prepregnancy weight was positively associated with all outcomes. GWG in all stages of pregnancy was positively associated with later BMI, WC, increased odds of overweight or obesity, and central adiposity. GWG in midpregnancy (19–28 wk) was associated with later greater SBP, DBP, and central adiposity but only in women with a normal prepregnancy BMI. Conclusions: Results support initiatives aimed at optimizing prepregnancy weight. Recommendations on optimal GWG need to balance contrasting associations with different outcomes in both mothers and offspring.
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影响因子：
7.2
作者：
Rooney, BL;Schauberger, CW;Mathiason, MA
通讯作者：
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影响因子：
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