Simultaneous detection of glutathione and lactate using spectral editing at 3 T.
Simultaneous detection of glutathione and lactate using spectral editing at 3 T.
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DOI：
10.1002/nbm.3800
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发表时间：
2017-12
影响因子：
2.9
通讯作者：
Barker PB
中科院分区：
文献类型：
--
作者：
Chan KL;Snoussi K;Edden RAE;Barker PB
描述并评价了两种用于在3 T下同时检测人脑中谷胱甘肽（GSH）和乳酸（Lac）的光谱编辑技术。这些方法，'sMEGA'和'DEW'，进行了优化，同时检测GSH和乳糖在3 T，使用密度矩阵模拟和验证幻影。还进行了模拟，以检测光谱中检测到的GSH区域内的共同编辑代谢物。在体内数据采集在中线顶骨区的7名受试者使用这两种方法，并与传统的MEGA-PRESS收购谷胱甘肽和紫胶。模拟和体模实验表明，sMEGA和DEW对GSH和Lac都具有较高的编辑效率。在体模中，GSH的编辑效率相对于常规GSH MEGA-PRESS采集>88%，而对于Lac，编辑效率相对于常规Lac MEGA-PRESS采集>95%。模拟还表明，这两种方法的编辑效率与相同代谢物的单独MEGA-PRESS采集相当。此外，模拟和在体内的光谱表明，在140毫秒的回波时间有Cr和GSH峰之间的部分重叠，NAA/NAAG从GSH充分解决。体内测量显示，sMEGA和DEW都以与相同代谢物的常规MEGA-PRESS采集相同的编辑效率可靠地编辑GSH和Lac，对于MEGA-PRESS，测量的GSH积分为2.23 ± .51、2.31 ± .38、2.38 ± .53，测量的Lac积分为1.72 ± .67、1.55 ± .35和1.53 ± .54。DEW和sMEGA。使用sMEGA和DEW可以在3 T下同时检测GSH和Lac，编辑效率高。描述并评价了两种用于在3 T下同时检测人脑中谷胱甘肽（GSH）和乳酸（Lac）的光谱编辑技术。优化同时光谱编辑方法（“sMEGA”和“DEW”）以同时检测GSH和Lac，模拟、体模和体内实验表明，sMEGA和DEW具有高GSH和Lac编辑效率，并且两种方法的编辑效率与相同代谢物的单独MEGA-PRESS采集相当。
Two spectral editing techniques for simultaneously detecting glutathione (GSH) and lactate (Lac) in the human brain at 3T are described and evaluated. These methods, ‘sMEGA’ and ‘DEW’, were optimized to detect GSH and Lac simultaneously at 3T, using density-matrix simulations and validation in phantoms. Simulations to test for co-edited metabolites within the detected GSH region of the spectrum were also performed. In vivo data were acquired in the midline parietal region of seven subjects using both methods and compared to conventional MEGA-PRESS acquisitions of GSH and Lac. Simulations and phantom experiments show that sMEGA and DEW have a high editing efficiency for both GSH and Lac. In the phantom, the editing efficiency of GSH was >88% relative to a conventional GSH MEGA-PRESS acquisition while for Lac, the editing efficiency was >95% relative to a conventional Lac MEGA-PRESS acquisition. Simulations also show that the editing efficiency of both methods is comparable to separate MEGA-PRESS acquisitions of the same metabolites. In addition, simulations and in vivo spectra show that at an echo time of 140 ms there is a partial overlap between Cr and GSH peaks and that NAA/NAAG are sufficiently resolved from GSH. In vivo measurements show that both sMEGA and DEW edit GSH and Lac reliably with the same editing efficiency as conventional MEGA-PRESS acquisitions of the same metabolites with measured GSH integrals of 2.23 ± .51, 2.31 ± .38, 2.38 ± .53 and measured Lac integrals of 1.72 ± .67, 1.55 ± .35, and 1.53 ± .54 for MEGA-PRESS, DEW, and sMEGA respectively. Simultaneous detection of GSH and Lac using sMEGA and DEW is possible at 3T with high editing efficiency. Two spectral editing techniques for simultaneously detecting glutathione (GSH) and lactate (Lac) in the human brain at 3T are described and evaluated. Simultaneous spectral editing methods (‘sMEGA’ and ‘DEW’) were optimized to detect GSH and Lac simultaneously, simulations, phantom, and in vivo experiments show that sMEGA and DEW have a high GSH and Lac editing efficiency and that the editing efficiency of both methods is comparable to separate MEGA-PRESS acquisitions of the same metabolites.
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3T 下大分子抑制 GABA 编辑的前瞻性频率校正。
影响因子：
4.4
作者：
Edden, Richard A. E.;Oeltzschner, Georg;Harris, Ashley D.;Puts, Nicolaas A. J.;Chan, Kimberly L.;Boer, Vincent O.;Schar, Michael;Barker, Peter B.
通讯作者：
Barker, Peter B.
影响因子：
4.4
作者：
Edden, Richard A. E.;Puts, Nicolaas A. J.;Harris, Ashley D.;Barker, Peter B.;Evans, C. John
通讯作者：
Evans, C. John
影响因子：
3.3
作者：
Simpson, Robin;Devenyi, Gabriel A.;Near, Jamie
通讯作者：
Near, Jamie
DOI：
10.1007/s10334-006-0050-2
发表时间：
2006-11-01
影响因子：
2.3
作者：
El-Sharkawy, Abdel Monem;Schar, Michael;Atalar, Ergin
通讯作者：
Atalar, Ergin
影响因子：
6.9
作者：
Rosa, A. R.;Singh, N.;Goodwin, G. M.
通讯作者：
Goodwin, G. M.