Prospective frequency correction for macromolecule-suppressed GABA editing at 3T.
Prospective frequency correction for macromolecule-suppressed GABA editing at 3T.
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3T 下大分子抑制 GABA 编辑的前瞻性频率校正。
DOI：
10.1002/jmri.25304
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发表时间：
2016-12
影响因子：
4.4
通讯作者：
Barker, Peter B.
中科院分区：
文献类型：
--
作者：
Edden, Richard A. E.;Oeltzschner, Georg;Harris, Ashley D.;Puts, Nicolaas A. J.;Chan, Kimberly L.;Boer, Vincent O.;Schar, Michael;Barker, Peter B.
已经提出了“对称”编辑方案来抑制GABA编辑中不需要的共同编辑的MM信号。研究B 0场偏移和漂移对大分子（MM）抑制GABA编辑实验的影响，并实施和测试前瞻性校正方案。全密度矩阵模拟的常规（非对称）和对称MM抑制编辑计划进行GABA自旋系统，以评估其偏移依赖性。进行了体模和体内（3 T下的15名受试者）GABA编辑的实验，其中大分子（MM）信号被对称抑制，以量化场偏移对总GABA+MM信号（指定为GABA+）的影响。实现了一种基于交错水参考（IWR）采集的前瞻性频率校正方法，并对其在正漂移和负漂移期间的实验性能进行了评估。仿真结果表明，从MM抑制的对称编辑方案的信号是一个数量级更容易受到场偏移比非对称编辑方案的信号。对于小的场偏移，MM抑制的GABA信号每Hz变化8.6%。IWR显著降低扫描仪偏移的场偏移和测量的GABA水平（通过F检验均为p<0.001）的方差，保持MM信号的对称抑制。对称编辑方案大大增加了测量对B 0场偏移的依赖性，这可能是由于患者移动和/或扫描仪不稳定性引起的。建议将对称编辑与有效的B 0稳定（如交错水参考提供的稳定）结合使用。
‘Symmetric’ editing schemes have been proposed to suppress unwanted co-edited MM signals in GABA editing. To investigate the effects of B0 field offsets and drift on macromolecule (MM) suppressed GABA-editing experiments, and to implement and test a prospective correction scheme. Full density-matrix simulations of both conventional (non-symmetric) and symmetric MM-suppressed editing schemes were performed for the GABA spin system to evaluate their offset-dependence. Phantom and in vivo (15 subjects at 3T) GABA-edited experiments with symmetrical suppression of macromolecular (MM) signals were performed to quantify the effects of field offsets on the total GABA+MM signal (designated as GABA+). A prospective frequency correction method based on interleaved water referencing (IWR) acquisitions was implemented and its experimental performance evaluated during positive and negative drift. Simulations show that the signal from MM-suppressed symmetrical editing schemes is an order of magnitude more susceptible to field offsets than the signal from non-symmetric editing schemes. The MM-suppressed GABA signal changes by 8.6% per Hz for small field offsets. IWR significantly reduces variance in the field offset and measured GABA levels (both p<0.001 by F-tests) the scanner offset, maintaining symmetric suppression of MM signal. Symmetrical editing schemes substantially increase the dependence of measurements on B0 field offsets, which can arise due to patient movement and/or scanner instability. It is recommended that symmetrical editing should be used in combination with effective B0 stabilization, such as that provided by interleaved water referencing.
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影响因子：
2.2
作者：
Star-Lack, J;Spielman, D;Vigneron, DB
通讯作者：
Vigneron, DB
影响因子：
4.4
作者：
Edden, Richard A. E.;Puts, Nicolaas A. J.;Harris, Ashley D.;Barker, Peter B.;Evans, C. John
通讯作者：
Evans, C. John
影响因子：
3.3
作者：
Bhattacharyya, P. K.;Lowe, M. J.;Phillips, M. D.
通讯作者：
Phillips, M. D.
影响因子：
2.9
作者：
Emir, Uzay E.;Raatz, Susan;McPherson, Susan;Hodges, James S.;Torkelson, Carolyn;Tawfik, Pierre;White, Tonya;Terpstra, Melissa
通讯作者：
Terpstra, Melissa
影响因子：
4.4
作者：
Evans, C. John;Puts, Nicolaas A. J.;Edden, Richard A. E.
通讯作者：
Edden, Richard A. E.