Novel fabrication of porous titanium by a resin-impregnated titanium substitution technique for bone reconstruction.
Novel fabrication of porous titanium by a resin-impregnated titanium substitution technique for bone reconstruction.
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DOI：
10.1039/c8ra08744j
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发表时间：
2019-01-09
期刊：
影响因子：
3.9
通讯作者：
Tsuga, Kazuhiro
中科院分区：
文献类型：
--
作者：
Kobatake, Reiko;Doi, Kazuya;Kubo, Takayasu;Makihara, Yusuke;Oki, Yoshifumi;Yokoi, Miyuki;Umehara, Hanako;Tsuga, Kazuhiro
本研究的目的是开发一种新型多孔钛材料，具有良好的机械强度和骨传导性，用于骨重建。采用钛浆料浸渍法制备了具有多种孔隙率(高孔率；92%，中孔率；85%和低孔率；65%)的多孔钛样品。以多孔HA(平均孔隙率为75.3%)为对照。为了评估这些材料的特性，我们进行了孔隙率测量、扫描电子显微镜(SEM)、三点弯曲测试和细胞增殖测试。为评价其骨传导能力，将多孔钛植入兔股骨内，3周后进行组织学和组织形态计量学评价。在扫描电子显微镜图像中，所有样品都观察到了多孔的三维结构。抗弯强度随孔隙率的增加而显著增加(分别为Ti-65和GT；Ti-85和GT；多孔HA>；Ti-92，P<；0.05)。Ti-65、Ti-85和多孔HA具有良好的细胞增殖能力。在钛-65、钛-85和多孔羟基磷灰石的中央部分可观察到新生骨。TI-92主要在骨髓组织中检测到。钛-65、钛-85和多孔羟基磷灰石的成骨面积显著高于钛-92(P<0.05)。提示由钛-65和钛-85组成的新型多孔钛具有良好的机械强度和骨传导性。本研究的目的是评估采用树脂浸渍钛替代制造技术的多孔钛结构的特征结构和骨传导能力。
The purpose of this study was to develop a novel porous titanium material with superior mechanical strength and osteoconduction for bone reconstruction. Porous titanium samples were fabricated by titanium-slurry impregnate to prepare urethane forms with several porosities (high-porosity; 92%, middle-porosity; 85% and low-porosity; 65%). Porous HA (mean porosity; 75.3%) was used as a control. To evaluate the characteristics of these materials, we performed porosity measurements, scanning electron microscopy (SEM), three-point bending testing, and cell proliferation assays. To evaluate the osteoconduction ability, porous titanium was placed into the femurs of rabbits and histological and histomorphometric evaluations were performed after 3 weeks. In SEM images, porous three-dimensional structures were observed in all samples. The bending strength significantly increased as porosity increased (Ti-65 > Ti-85 > porous HA > Ti-92, P < 0.05; respectively). Ti-65, Ti-85, and porous HA showed good cell proliferation. Newly formed bone was observed in the central portion of Ti-65, Ti-85, and porous HA. Ti-92 was mainly detected in the bone marrow tissue. The bone formation areas of Ti-65, Ti-85, and porous HA were significantly higher than that of Ti-92 (P < 0.05). It was suggested that novel developed porous titanium composed of Ti-65 and Ti-85 showed superior mechanical strength and osteoconduction. The purpose of this study was to evaluate the characteristic structures and osteoconduction ability of porous titanium structures using a resin-impregnated titanium substitution fabrication technique.
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影响因子：
1.2
作者：
Oh, IH;Nomura, N;Hanada, S
通讯作者：
Hanada, S
影响因子：
3.6
作者：
Kubo, Takayasu;Doi, Kazuya;Akagawa, Yasumasa
通讯作者：
Akagawa, Yasumasa
影响因子：
1.4
作者：
Semel, F. J.;Lados, D. A.
通讯作者：
Lados, D. A.
影响因子：
14
作者：
Ho, WF;Ju, CP;Lin, JHC
通讯作者：
Lin, JHC
影响因子：
9.7
作者：
Levingstone, Tanya J.;Thompson, Emmet;O'Brien, Fergal J.
通讯作者：
O'Brien, Fergal J.