Connecting the ear to the brain: Molecular mechanisms of auditory circuit assembly.
Connecting the ear to the brain: Molecular mechanisms of auditory circuit assembly.
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DOI：
10.1016/j.pneurobio.2011.01.004
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发表时间：
2011-04
影响因子：
6.7
通讯作者：
Goodrich LV
中科院分区：
文献类型：
--
作者：
Appler JM;Goodrich LV
我们的听觉依赖于精确组织的电路，使我们能够感知，感知和响应环境中的复杂声音，从音乐和语言到简单的警告信号。听觉处理开始于内耳的耳蜗，在那里声音被感觉毛细胞检测到，然后通过螺旋神经节神经元传递到中枢神经系统，这些神经元忠实地保留每个刺激的频率，强度和时间。在听觉回路的组装过程中，螺旋神经节神经元建立精确的连接，将耳蜗中的毛细胞与听觉脑干中的靶神经元连接起来，发展出特定的放电特性，并在外周和中枢神经系统中形成不寻常的突触。了解螺旋神经节神经元如何获得这些独特的特性是听觉神经科学的一个关键目标，因为这些神经元代表了听觉信息到大脑的唯一输入。此外，目前对多种耳聋的最佳治疗方法是人工耳蜗植入，它通过直接刺激听觉神经来补偿失去的毛细胞功能。从历史上看，对听觉系统的研究一直落后于其他感觉系统，因为内耳的体积小，难以接近。随着新的分子遗传工具的出现，这一差距正在缩小。在这里，我们总结了最近的见解，引导螺旋神经节神经元的发展，从他们的起源在proneurosensory域的耳泡专门的突触，确保快速和可靠的声音信息从耳朵到大脑的传输形成的细胞和分子线索。
Our sense of hearing depends on precisely organized circuits that allow us to sense, perceive, and respond to complex sounds in our environment, from music and language to simple warning signals. Auditory processing begins in the cochlea of the inner ear, where sounds are detected by sensory hair cells and then transmitted to the central nervous system by spiral ganglion neurons, which faithfully preserve the frequency, intensity, and timing of each stimulus. During the assembly of auditory circuits, spiral ganglion neurons establish precise connections that link hair cells in the cochlea to target neurons in the auditory brainstem, develop specific firing properties, and elaborate unusual synapses both in the periphery and in the CNS. Understanding how spiral ganglion neurons acquire these unique properties is a key goal in auditory neuroscience, as these neurons represent the sole input of auditory information to the brain. In addition, the best currently available treatment for many forms of deafness is the cochlear implant, which compensates for lost hair cell function by directly stimulating the auditory nerve. Historically, studies of the auditory system have lagged behind other sensory systems due to the small size and inaccessibility of the inner ear. With the advent of new molecular genetic tools, this gap is narrowing. Here, we summarize recent insights into the cellular and molecular cues that guide the development of spiral ganglion neurons, from their origin in the proneurosensory domain of the otic vesicle to the formation of specialized synapses that ensure rapid and reliable transmission of sound information from the ear to the brain.
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DOI：
10.1242/dev.029330
发表时间：
2008-12
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Abraira VE;Del Rio T;Tucker AF;Slonimsky J;Keirnes HL;Goodrich LV
通讯作者：
Goodrich LV
影响因子：
2.7
作者：
Alsina, B;Abelló, G;Giraldez, F
通讯作者：
Giraldez, F
DOI：
10.1007/s10162-008-0110-6
发表时间：
2008-03-01
影响因子：
2.4
作者：
Braunstein, Evan M.;Crenshaw, E. Bryan, III;Adams, Joe C.
通讯作者：
Adams, Joe C.
影响因子：
6.2
作者：
Birchmeier, Carmen;Nave, Klaus-Armin
通讯作者：
Nave, Klaus-Armin
影响因子：
2.5
作者：
ANNIKO, M;WIKSTROM, SO
通讯作者：
WIKSTROM, SO