Mechanical profiling of intervertebral discs.
Mechanical profiling of intervertebral discs.
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DOI：
10.1016/j.jbiomech.2009.02.013
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发表时间：
2009-05-29
影响因子：
2.4
通讯作者：
Lotz JC
中科院分区：
文献类型：
--
作者：
Schultz DS;Rodriguez AG;Hansma PK;Lotz JC
尽管最近在影像诊断技术和其他治疗选择方面取得了进步，但我们预防或抑制椎间盘源性背痛的能力并没有显著改善。将早期退变模式与功能障碍和疼痛联系起来仍然是一个挑战。使用一种名为组织诊断仪(TDI)的新型材料测试设备，我们测量了13个完整椎间盘的局部刚度和径向应变能吸收，有效地生成了每个椎间盘的力学轮廓。在测量机械性能之前，对每个脊柱节段进行MR成像，并根据Pfirmann分级对椎间盘进行放射学评分。在测试后，从四个脊柱的每个椎体上切除每个L1-L2椎体的矢状面部分以进行组织学检查。在Pfirmann分级和力学数据之间没有发现显著的相关性。然而，椎间盘切片的偏振光学显微镜图像表明，用TDI测量的局部组织模数与板层条纹的清晰度和密度之间存在相关性。
Despite recent advances in imaging diagnostic technology and additional treatment options our ability to prevent or inhibit discogenic back pain has not drastically improved. The challenge of linking early degenerative patterns to dysfunction and pain remains. Using a novel material testing device designated the Tissue Diagnostic Instrument (TDI) we measured the local stiffness and strain energy absorption in the radial direction of 13 intact intervertebral discs; effectively generating a mechanical profile of each disc. Prior to measuring mechanical properties, an MR image was taken of each spine segment and the discs were radiologically scored according to the Pfirrmann scale. After testing, a sagittal portion of each L1-L2 disc was excised from each of four spines for histology. No significant correlations were found between Pfirrmann grade and mechanical data. However, polarized light microscopy images of disc sections indicated correlations between local tissue modulus measured with the TDI and the clarity and density of lamellar striations.
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影响因子：
3
作者：
THOMPSON, JP;PEARCE, RH;BISHOP, PB
通讯作者：
BISHOP, PB
影响因子：
2.9
作者：
CASSIDY, JJ;HILTNER, A;BAER, E
通讯作者：
BAER, E
影响因子：
3.4
作者：
Stoller, P;Reiser, KM;Rubenchik, AM
通讯作者：
Rubenchik, AM
影响因子：
4.9
作者：
Urban JP;Roberts S
通讯作者：
Roberts S
影响因子：
2.4
作者：
Bass, EC;Wistrom, EV;Lotz, JC
通讯作者：
Lotz, JC