Pathogens in Vasculitis: Is It Really Idiopathic?
Pathogens in Vasculitis: Is It Really Idiopathic?
复制标题
DOI：
10.31662/jmaj.2021-0021
复制
发表时间：
2021-07-15
期刊：
影响因子：
--
通讯作者：
Ishiguro N
中科院分区：
文献类型：
--
作者：
Miyabe C;Miyabe Y;Miyata R;Ishiguro N
血管炎是一种以血管内白细胞浸润为特征的自身免疫性疾病。越来越多的人类和动物模型研究表明多种微生物与血管炎的发病机制有关。先前的研究表明，患病血管中存在传染源，包括病毒、细菌和真菌。然而，尽管研究不断进行，但感染和血管炎之间的联系尚未完全了解，这可能是由于缺乏反映人类疾病的适当动物模型以及血管中病原体检测的技术限制。在病原体诱导的动物模型中，白色念珠菌水溶性成分（CAWS）诱导的冠状动脉炎目前被认为是川崎病（KD）的代表性模型之一。宏基因组下一代测序的进步已经能够检测组织中的所有核酸，这可以帮助识别候选病原体，包括以前未识别的病毒。在这篇综述中，我们讨论了动物模型和人类病原体相关血管炎报告的发现，特别关注血管炎发病机制的研究。对动物模型和患病血管中微生物的进一步研究可能会为血管炎的发病机制提供重要的见解，血管炎通常被认为是一种特发性疾病。
Vasculitis is an autoimmune disease characterized by the infiltration of leukocytes in blood vessels. An increasing number of studies on human and animal models have implicated various microorganisms in the pathogenesis of vasculitis. Previous studies have shown the presence of infectious agents, including viruses, bacteria, and fungi, in diseased vessels. However, despite continued research, the link between infection and vasculitis is not fully understood, possibly owing to the lack of appropriate animal models that mirror human disease and the technical limitations of pathogen detection in blood vessels. Among the pathogen-induced animal models, Candida albicans water-soluble fraction (CAWS)-induced coronary arteritis is currently considered one of the representative models of Kawasaki (KD) disease. Advances in metagenomic next-generation sequencing have enabled the detection of all nucleic acids in tissue, which can help identify candidate pathogens, including previously unidentified viruses. In this review, we discuss the findings from reports on pathogen-associated vasculitis in animal models and humans, with a specific focus on the investigation of the pathogenesis of vasculitis. Further studies on animal models and microbes in diseased vessels may provide important insights into the pathogenesis of vasculitis, which is often considered an idiopathic disease.
DOI：
10.1016/0007-1935(92)90044-2
发表时间：
1992-05
期刊：
The British veterinary journal
影响因子：
--
作者：
Chirnside ED
通讯作者：
Chirnside ED