Vascepa protects against high-fat diet-induced glucose intolerance, insulin resistance, and impaired β-cell function.
Vascepa protects against high-fat diet-induced glucose intolerance, insulin resistance, and impaired β-cell function.
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Vascepa可预防高脂饮食诱导的葡萄糖耐受不良、胰岛素抵抗和β细胞功能受损。
DOI：
10.1016/j.isci.2021.102909
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发表时间：
2021-08-20
期刊：
影响因子：
5.8
通讯作者：
Wheeler MB
中科院分区：
文献类型：
--
作者：
Al Rijjal D;Liu Y;Lai M;Song Y;Danaei Z;Wu A;Mohan H;Wei L;Schopfer FJ;Dai FF;Wheeler MB
ω-3脂肪酸处方药Vascepa（≥ 96%二十碳五烯酸[EPA]乙酯）和Lovaza（46.5% EPA和37.5%二十二碳六烯酸乙酯）是治疗高脂血症的已知治疗方案。然而，它们对葡萄糖稳态、进展为2型糖尿病和胰腺β细胞功能的影响尚不清楚。在本研究中，小鼠在高脂饮食喂养6周之前用Vascepa或Lovaza治疗1周。Vascepa而不是Lovaza导致胰岛素抵抗降低，空腹胰岛素和葡萄糖减少，葡萄糖耐受不良改善。Vascepa改善了β细胞功能，降低了肝脏甘油三酯，增强了肝脏脂肪酸氧化基因的表达，并改变了微生物群的组成。Vascepa对饮食诱导的小鼠胰岛素抵抗和葡萄糖耐受不良具有保护作用。Vascepa是一种EPA乙酯处方药，可防止饮食诱导的体重增加急性暴露于Vascepa可防止葡萄糖耐受不良和β细胞功能障碍改善胰岛功能与改善胰岛素抵抗相关Vascepa上调肝脏脂肪酸氧化基因并改变肠道微生物组膳食补充剂;人体代谢
Omega-3 fatty acid prescription drugs, Vascepa (≥96% eicosapentaenoic acid [EPA] ethyl ester) and Lovaza (46.5% EPA and 37.5% docosahexaenoic acid ethyl ester) are known therapeutic regimens to treat hypertriglyceridemia. However, their impact on glucose homeostasis, progression to type 2 diabetes, and pancreatic beta cell function are not well understood. In the present study, mice were treated with Vascepa or Lovaza for one week prior to six weeks of high-fat diet feeding. Vascepa but not Lovaza led to reduced insulin resistance, reduced fasting insulin and glucose, and improved glucose intolerance. Vascepa improved beta cell function, reduced liver triglycerides with enhanced expression of hepatic fatty acid oxidation genes, and altered microbiota composition. Vascepa has protective effects on diet-induced insulin resistance and glucose intolerance in mice. Vascepa, an EPA ethyl ester prescription drug, protects from diet-induced weight gain Acute exposure to Vascepa protects from glucose intolerance and beta cell dysfunction Improved islet function is associated with improved insulin resistance Vascepa upregulates hepatic fatty acid oxidation genes and alters gut microbiome Dietary supplement; Human metabolism
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影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
2
作者：
Jacobson, Terry A.
通讯作者：
Jacobson, Terry A.
影响因子：
5.4
作者：
de Castro GS;Deminice R;Simões-Ambrosio LM;Calder PC;Jordão AA;Vannucchi H
通讯作者：
Vannucchi H
影响因子：
3.7
作者：
Ghosh S;DeCoffe D;Brown K;Rajendiran E;Estaki M;Dai C;Yip A;Gibson DL
通讯作者：
Gibson DL
DOI：
10.1097/mco.0b013e328342991c
发表时间：
2011-03
影响因子：
3.1
作者：
Jump DB
通讯作者：
Jump DB