Dietary docosahexaenoic acid and eicosapentaenoic acid influence liver triacylglycerol and insulin resistance in rats fed a high-fructose diet.
Dietary docosahexaenoic acid and eicosapentaenoic acid influence liver triacylglycerol and insulin resistance in rats fed a high-fructose diet.
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DOI：
10.3390/md13041864
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发表时间：
2015-04-01
期刊：
影响因子：
5.4
通讯作者：
Vannucchi H
中科院分区：
文献类型：
--
作者：
de Castro GS;Deminice R;Simões-Ambrosio LM;Calder PC;Jordão AA;Vannucchi H
本研究旨在研究鱼油（FO）中不同量的omega-3（n-3）多不饱和脂肪酸对高果糖饮食大鼠脂质代谢、胰岛素抵抗和基因表达的益处。将雄性Wistar大鼠分为两组：对照组（C，n = 6）和果糖组（Fr，n = 32），后者接受含63%重量果糖的饮食60天。在此期间之后，来自Fr组的24只动物被分配到三个组：FrFO 2（n = 8）接受63%果糖和2%FO加5%大豆油; FrFO 5（n = 8）接受63%果糖和5%FO加2%大豆油;和FrFO 7（n = 8）接受63%果糖和7%FO。动物喂食这些饲料30天。果糖导致肝脏重量、肝脏和血清三酰甘油、血清丙氨酸氨基转移酶和HOMA 1-IR指数增加。这些改变被5%和7%的FO逆转。FO对肝脏β-氧化（增加）和肝脏脂肪生成（减少）相关基因的表达具有剂量依赖性影响。接受最高FO量的组具有增加的氧化应激标志物。它的结论是，n-3脂肪酸可能能够扭转由高果糖饮食引起的不良代谢效应。
This study aimed to examine the benefits of different amounts of omega-3 (n-3) polyunsaturated fatty acids from fish oil (FO) on lipid metabolism, insulin resistance and gene expression in rats fed a high-fructose diet. Male Wistar rats were separated into two groups: Control (C, n = 6) and Fructose (Fr, n = 32), the latter receiving a diet containing 63% by weight fructose for 60 days. After this period, 24 animals from Fr group were allocated to three groups: FrFO2 (n = 8) receiving 63% fructose and 2% FO plus 5% soybean oil; FrFO5 (n = 8) receiving 63% fructose and 5% FO plus 2% soybean oil; and FrFO7 (n = 8) receiving 63% fructose and 7% FO. Animals were fed these diets for 30 days. Fructose led to an increase in liver weight, hepatic and serum triacylglycerol, serum alanine aminotransferase and HOMA1-IR index. These alterations were reversed by 5% and 7% FO. FO had a dose-dependent effect on expression of genes related to hepatic β-oxidation (increased) and hepatic lipogenesis (decreased). The group receiving the highest FO amount had increased markers of oxidative stress. It is concluded that n-3 fatty acids may be able to reverse the adverse metabolic effects induced by a high fructose diet.
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影响因子：
5.1
作者：
McCullough, Arthur J
通讯作者：
McCullough, Arthur J
影响因子：
7.1
作者：
Kris-Etherton, PM;Taylor, DS;Etherton, TD
通讯作者：
Etherton, TD
影响因子：
6
作者：
Calder, Philip C.;Yaqoob, Parveen
通讯作者：
Yaqoob, Parveen
影响因子：
2.8
作者：
Miller, Michael;Ginsberg, Henry N.;Schaefer, Ernst J.
通讯作者：
Schaefer, Ernst J.
DOI：
10.1016/j.plefa.2012.11.003
发表时间：
2013-02-01
影响因子：
3
作者：
D'Alessandro, Maria E.;Chicco, Adriana;Lombardo, Yolanda B.
通讯作者：
Lombardo, Yolanda B.