Alcohol Consumption Accumulation of Monocyte Derived Macrophages in Female Mice Liver Is Interferon Alpha Receptor Dependent.
Alcohol Consumption Accumulation of Monocyte Derived Macrophages in Female Mice Liver Is Interferon Alpha Receptor Dependent.
复制标题
DOI：
10.3389/fimmu.2021.663548
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Aloman C
中科院分区：
文献类型：
--
作者：
Alharshawi K;Fey H;Vogle A;Klenk T;Kim M;Aloman C
单核细胞在骨髓中从造血干细胞发育而来，并代表循环中的异质吞噬细胞。在稳态和炎症条件下，在募集到组织中后，单核细胞分化成巨噬细胞和树突状细胞。酒精使用每年导致全球约330万人死亡，约占所有死亡人数的5.9%。在美国和欧洲，酒精使用障碍是第五大死亡原因。在人类和小鼠中，女性更容易受到酒精性肝损伤的影响。值得注意的是，我们仍然不知道这种组织损伤的差异有多少是由于酒精及其毒性代谢物对a）实质或驻留细胞和/或B）对酒精的免疫反应的差异效应。因此，我们使用小鼠慢性酒精暴露模型，通过使用免疫表型表征来研究单核细胞的动态，单核细胞是一种先天免疫细胞类型，在酒精性肝损伤中至关重要。我们的数据揭示了雌性小鼠肝脏单核细胞酒精反应的性别二型性，这是干扰素受体α依赖性的。这种二态性可能揭示了潜在的细胞机制，以解释女性对酒精性免疫发病机制的易感性，并提出了女性酒精性肝损伤的另一个靶向途径。
Monocytes develop in the bone marrow from the hematopoietic stem cells and represent heterogeneous phagocyte cells in the circulation. In homeostatic and inflammatory conditions, after recruitment into tissues, monocytes differentiate into macrophages and dendritic cells. Alcohol use causes about 3.3 million worldwide deaths per year, which is about 5.9% of all deaths. In the United States and Europe, alcohol use disorders represent the fifth leading cause of death. Females are more susceptible to alcoholic liver injury in both humans and mice. Strikingly, we still do not know how much of this difference in tissue injury is due to the differential effect of alcohol and its toxic metabolites on a) parenchymal or resident cells and/or b) immune response to alcohol. Therefore, we used a model of chronic alcohol exposure in mice to investigate the dynamics of monocytes, an innate immune cell type showed to be critical in alcoholic liver injury, by using immunophenotypic characterization. Our data reveal a sex-dimorphism of alcohol response of hepatic monocytes in female mice that is interferon receptor alpha dependent. This dimorphism could shed light on potential cellular mechanism(s) to explain the susceptibility of females to alcoholic immunopathogenesis and suggests an additional targetable pathway for alcoholic liver injury in females.
登录
查看更多内容
DOI：
10.1002/hep.23009
发表时间：
2009-08
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Rao R
通讯作者：
Rao R
影响因子：
5.6
作者：
Alharshawi K;Fey H;Vogle A;Klenk T;Kim M;Aloman C
通讯作者：
Aloman C
影响因子：
4.6
作者：
Lasseaux, Corentin;Fourmaux, Marie-Pierre;Poulin, Lionel Franz
通讯作者：
Poulin, Lionel Franz
DOI：
10.1084/jem.20141539
发表时间：
2015-04-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dal-Secco D;Wang J;Zeng Z;Kolaczkowska E;Wong CH;Petri B;Ransohoff RM;Charo IF;Jenne CN;Kubes P
通讯作者：
Kubes P
影响因子：
4.4
作者：
Meyerholz, David K.;Edsen-Moore, Michelle;Legge, Kevin L.
通讯作者：
Legge, Kevin L.