Reward vs. Retaliation-the Role of the Mesocorticolimbic Salience Network in Human Reactive Aggression.
Reward vs. Retaliation-the Role of the Mesocorticolimbic Salience Network in Human Reactive Aggression.
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DOI：
10.3389/fnbeh.2016.00179
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发表时间：
2016
影响因子：
3
通讯作者：
Alia-Klein N
中科院分区：
文献类型：
--
作者：
Gan G;Preston-Campbell RN;Moeller SJ;Steinberg JL;Lane SD;Maloney T;Parvaz MA;Goldstein RZ;Alia-Klein N
反应性攻击(RA)是对刺激的反应，在健康成年人中，这种倾向与大脑皮质边缘奖赏网络的高反应性有关。在这里，我们旨在阐明中皮质边缘网络在两种相互竞争的动机行为--寻求奖励与报复--的类风湿性关节炎中的作用。18名男性参与者在功能磁共振成像(FMRI)期间进行了一种变种的点减法攻击范式(PSAP)。我们考察了RA参与者与非攻击性控制相比，是否会选择获得金钱奖励，而不是有机会报复虚构的对手，后者通过随机从参与者的收入中窃取金钱来挑衅参与者。在所有的fMRI-PSAP运行中，RA患者与对照组相比，选择了更努力地工作来赚钱，但不进行报复。在单次fMRI-PSAP测试中，当参与这种寻求奖励行为与报复行为时，与对照组相比，类风湿关节炎患者中皮质边缘突起网络的岛状-纹状体部分的激活增加，而楔前和腹内侧额叶皮质的激活减少。类风湿性关节炎个体整体奖赏寻求行为的增强，以及中皮质边缘显著网络的上调和默认模式网络的下调，表明类风湿性关节炎患者在面临选择时，愿意为金钱奖励而不是报复而工作。我们的发现可能表明，积极强化的使用可能是一种有效的干预方法，以减少潜在的报复行为在临床意义上的类风湿关节炎。
The propensity for reactive aggression (RA) which occurs in response to provocation has been linked to hyperresponsivity of the mesocorticolimbic reward network in healthy adults. Here, we aim to elucidate the role of the mesocorticolimbic network in clinically significant RA for two competing motivated behaviors, reward-seeking vs. retaliation. 18 male participants performed a variant of the Point-Subtraction Aggression Paradigm (PSAP) during functional magnetic resonance imaging (fMRI). We examined whether RA participants compared with non-aggressive controls would choose to obtain a monetary reward over the opportunity to retaliate against a fictitious opponent, who provoked the participant by randomly stealing money from his earnings. Across all fMRI-PSAP runs, RA individuals vs. controls chose to work harder to earn money but not to retaliate. When engaging in such reward-seeking behavior vs. retaliation in a single fMRI-PSAP run, RA individuals exhibited increased activation in the insular-striatal part of the mesocorticolimbic salience network, and decreased precuneus and ventromedial prefrontal cortex activation compared to controls. Enhanced overall reward-seeking behavior along with an up-regulation of the mesocorticolimbic salience network and a down-regulation of the default-mode network in RA individuals indicate that RA individuals are willing to work more for monetary reward than for retaliation when presented with a choice. Our findings may suggest that the use of positive reinforcement might represent an efficacious intervention approach for the potential reduction of retaliatory behavior in clinically significant RA.
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影响因子：
5.7
作者：
Bartra, Oscar;McGuire, Joseph T.;Kable, Joseph W.
通讯作者：
Kable, Joseph W.
影响因子：
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作者：
Coccaro, Emil F.;Lee, Royce;McCloskey, Michael S.
通讯作者：
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影响因子：
25
作者：
Buckholtz, Joshua W.;Treadway, Michael T.;Cowan, Ronald L.;Woodward, Neil D.;Benning, Stephen D.;Li, Rui;Ansari, M. Sib;Baldwin, Ronald M.;Schwartzman, Ashley N.;Shelby, Evan S.;Smith, Clarence E.;Cole, David;Kessler, Robert M.;Zald, David H.
通讯作者：
Zald, David H.
影响因子：
5.3
作者：
Coccaro, EF;Posternak, MA;Zimmerman, M
通讯作者：
Zimmerman, M
影响因子：
3.6
作者：
CHEREK, DR;SPIGA, R;COWAN, KA
通讯作者：
COWAN, KA