Some properties of sodium and chloride channels in respiratory epithelia of CF- and non-CF-patients.
Some properties of sodium and chloride channels in respiratory epithelia of CF- and non-CF-patients.
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CF 和非 CF 患者呼吸道上皮细胞中钠离子和氯离子通道的一些特性。
DOI：
10.1007/978-1-4684-5934-0_15
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发表时间：
1991
影响因子：
--
通讯作者：
E. Frömter
中科院分区：
文献类型：
--
作者：
J. Disser;A. Hazama;E. Frömter
Thus far patch clamp studies on single channel properties of respiratory epithelia have mainly focussed on Cl- channels (9, 10, 13, 15, 16, 21, 23). This has been so for two reasons: 1. The disturbance in Cl- conductance was the first transport defect to be discovered in CF epithelia (19, 22) and 2. In single channel studies on respiratory epithelia Cl- channels are found more frequently and identified and studied more easily than the low conductance, slowly switching Na+ channels. On the other hand, however, it has been known for almost ten years that sodium transport is increased in CF epithelia (12) and this alteration of sodium transport may even be more relevant as a pathogenetic factor since it may affect the transepithelial fluid balance in the bronchi more than the inability to secrete chloride (see contribution by Boucher and collaborators to this symposium). In the present paper, therefore, we shall mainly discuss our recent studies on properties of Na+ channels and shall, at the end, only briefly mention some of our recent experiments concerning the regulation of Cl- channels.
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DOI：
--
发表时间：
1986-11
期刊：
Federation proceedings
影响因子：
--
作者：
L. Palmer;G. Frindt
通讯作者：
L. Palmer;G. Frindt
影响因子：
56.9
作者：
J. Riordan;J. Rommens;N. Alon;R. Rozmahel;Z. Grzelczak;J. Zieleński;N. Plavsic;Jia-Ling Chou
通讯作者：
J. Riordan;J. Rommens;N. Alon;R. Rozmahel;Z. Grzelczak;J. Zieleński;N. Plavsic;Jia-Ling Chou
DOI：
10.1073/pnas.83.8.2767
发表时间：
1986-04-01
影响因子：
11.1
作者：
PALMER, LG;FRINDT, G
通讯作者：
FRINDT, G
正常和囊性纤维化气道上皮中蛋白激酶 C 对氯离子通道的调节。
DOI：
10.1126/science.2472006
发表时间：
1989
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Li,M;McCann,JD;Anderson,MP;Clancy,JP;Liedtke,CM;Nairn,AC;Greengard,P;Welsch,MJ
通讯作者：
Welsch,MJ
CF 中的 Cl- 通道：缺乏蛋白激酶 C 和 cAMP 依赖性蛋白激酶的激活。
DOI：
10.1126/science.2472005
发表时间：
1989
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hwang,TC;Lu,L;Zeitlin,PL;Gruenert,DC;Huganir,R;Guggino,WB
通讯作者：
Guggino,WB