Mn-single-atom nano-multizyme enabled NIR-II photoacoustically monitored, photothermally enhanced ROS storm for combined cancer therapy.
Mn-single-atom nano-multizyme enabled NIR-II photoacoustically monitored, photothermally enhanced ROS storm for combined cancer therapy.
复制标题
锰单原子纳米复合酶启用 NIR-II 光声监测、光热增强 ROS 风暴，用于联合癌症治疗。
DOI：
10.1186/s40824-023-00464-w
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发表时间：
2023-12-04
影响因子：
11.3
通讯作者：
Zhang R
中科院分区：
文献类型：
--
作者：
Wang X;Ren X;Yang J;Zhao Z;Zhang X;Yang F;Zhang Z;Chen P;Li L;Zhang R
实现具有最小副作用的成像引导的多模态癌症治疗仍然具有高度挑战性。我们设计了一种仿生中空氮掺杂碳球锚定与单独分散的锰原子（Mn/N-HCN）通过氧化聚合与Triton胶束作为软模板，然后碳化和退火。进行酶动力学分析和光学性质以评估成像引导的光热协同纳米催化疗法。这种纳米多酶同时模拟多种天然酶，即过氧化物酶（POD）、过氧化氢酶（CAT）、氧化酶（OXD）和谷胱甘肽过氧化物酶（GPx），能够在没有外部能量输入的情况下通过并联和串联催化反应产生具有高度细胞毒性的羟基自由基（·OH）和单线态氧（1 O2），并抑制肿瘤中上调的抗氧化剂（谷胱甘肽）。此外，吸收Mn/N-HCN的NIR-II允许光热疗法（PTT）、CAT活性的增强和光声（PA）成像以监测纳米酶的累积动力学和原位催化过程。体外和体内实验均表明，近红外-II（NIR-II）PA成像引导的光热增强和协同纳米催化疗法可有效诱导癌细胞凋亡并根除肿瘤组织。这项研究不仅展示了一种有效的癌症诊断和治疗的新方法，而且为设计多功能纳米酶提供了新的见解。在线版本包含补充材料，可通过10.1186/s40824-023-00464-w获得。
To realize imaging-guided multi-modality cancer therapy with minimal side effects remains highly challenging. We devised a bioinspired hollow nitrogen-doped carbon sphere anchored with individually dispersed Mn atoms (Mn/N-HCN) via oxidation polymerization with triton micelle as a soft template, followed by carbonization and annealing. Enzyme kinetic analysis and optical properties were performed to evaluate the imaging-guided photothermally synergized nanocatalytic therapy. Simultaneously mimicking several natural enzymes, namely peroxidase (POD), catalase (CAT), oxidase (OXD), and glutathione peroxidase (GPx), this nano-multizyme is able to produce highly cytotoxic hydroxyl radical (•OH) and singlet oxygen (1O2) without external energy input through parallel and series catalytic reactions and suppress the upregulated antioxidant (glutathione) in tumor. Furthermore, NIR-II absorbing Mn/N-HCN permits photothermal therapy (PTT), enhancement of CAT activity, and photoacoustic (PA) imaging to monitor the accumulation kinetics of the nanozyme and catalytic process in situ. Both in vitro and in vivo experiments demonstrate that near-infrared-II (NIR-II) PA-imaging guided, photothermally enhanced and synergized nanocatalytic therapy is efficient to induce apoptosis of cancerous cells and eradicate tumor tissue. This study not only demonstrates a new method for effective cancer diagnosis and therapy but also provides new insights into designing multi-functional nanozymes. The online version contains supplementary material available at 10.1186/s40824-023-00464-w.
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