Neuronal correlates of affective theory of mind in schizophrenia out-patients: evidence for a baseline deficit
Neuronal correlates of affective theory of mind in schizophrenia out-patients: evidence for a baseline deficit
复制标题
精神分裂症门诊患者情感心理理论的神经元相关性：基线缺陷的证据
作者：
D. Mier;C. Sauer;Stefanie Lis;C. Esslinger;J. Wilhelm;Bernd Gallhofer;Peter Kirsch
精神分裂症门诊患者不仅在情感心理理论（ToM）方面存在缺陷，而且在更基础的社会认知水平上也存在缺陷，如中性和情绪表达的处理。这些缺陷与杏仁核和上级颞沟（STS）的大脑激活变化有关。然而，到目前为止，还没有研究在一个设计中检查这些不同水平的社会认知及其神经生物学基础。方法采用功能磁共振成像（fMRI）技术，对16例精神分裂症患者和16例健康对照者进行情感心理理论（aToM）、情绪识别和中性面部表情加工的社会认知任务研究。结果患者存在情绪识别障碍，aToM障碍更为突出。在对照组中，aToM和情绪识别的表现相关，但在精神分裂症组中不相关。功能性脑成像数据的感兴趣区域分析显示，在aToM过程中，两组之间没有差异，但在情绪识别和中性面部表情处理过程中，精神分裂症组的左杏仁核和右STS过度激活。结论门诊精神分裂症患者在多个社会认知水平上存在缺陷，并首次证明精神分裂症患者高阶社会认知过程的缺陷可追溯到面孔本身的异常加工。
Background Schizophrenia out-patients have deficits in affective theory of mind (ToM) but also on more basal levels of social cognition, such as the processing of neutral and emotional expressions. These deficits are associated with changes in brain activation in the amygdala and the superior temporal sulcus (STS). However, until now there have been no studies that examined these different levels of social cognition and their neurobiological underpinnings in patients within one design. Method Sixteen medicated schizophrenia out-patients and 16 matched healthy controls were studied with functional magnetic resonance imaging (fMRI) during a social cognition task that allows the investigation of affective ToM (aToM), emotion recognition and the processing of neutral facial expressions. Results Patients showed a deficit in emotion recognition and a more prominent deficit in aToM. The performance in aToM and in emotion recognition was correlated in the control group but not in the schizophrenia group. Region-of-interest analysis of functional brain imaging data revealed no difference between groups during aToM, but a hyperactivation in the schizophrenia group in the left amygdala and right STS during emotion recognition and the processing of neutral facial expressions. Conclusions The results indicate that schizophrenia out-patients have deficits at several levels of social cognition and provide the first evidence that deficits on higher-order social cognitive processes in schizophrenia may be traced back to an aberrant processing of faces per se.
影响因子：
17.7
作者：
Callicott, JH;Mattay, VS;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
17.7
作者：
Gur, RE;McGrath, C;Gur, RC
通讯作者：
Gur, RC
影响因子：
6.6
作者：
Andreasen, Nancy C.;Calage, Chadi A.;O'Leary, Daniel S.
通讯作者：
O'Leary, Daniel S.